[Influence of chronic obstructive pulmonary disease on hospital outcomes of percutaneous coronary interventions in patients with acute coronary syndrome].

Aim: To evaluate the impact of chronic obstructive pulmonary disease (COPD) on hospital outcomes of percutaneous coronary interventions (PCI) in patients with acute coronary syndrome (ACS).

Materials And Methods: A cohort prospective study of the COPD effect on mortality and coronary microvascular obstruction (CMVO, no-reflow) development after PCI in ACS was carried out. 626 patients admitted in 2019-2020 were included, 418 (67%) - men, 208 (33%) - women.

[Use of metformin in patients with type 2 diabetes and acute myocardial infarction: safety and impact on glycemic control].

Background: Myocardial infarction (MI) in patients with diabetes type 2 (T2DM) occurs 1.5-3.0 times higher than in general population.

[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].

Background: There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).

Aim: To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.

[ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis].

Aim: Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection.

Materials And Methods: The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home.

Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»).

Aim      To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material and methods  The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients' privacy (data of nasal and throat smears; antibody titer; typical CT imaging features).

Using an Artificial Neural Network to Predict Coronary Microvascular Obstruction (No-Reflow Phenomenon) during Percutaneous Coronary Interventions in Patients with Myocardial Infarction.

Unlabelled: was to develop, evaluate, and validate an artificial neural network to predict coronary microvascular obstruction (CMVO) during percutaneous coronary interventions (PCI) in patients with myocardial infarctions (MI) based on the parameters, which are routinely available in an operating room when choosing a surgical approach.

Materials And Methods: 5621 patients with MI and emergency PCI were retrospectively selected from the database of the City Clinical Hospital No.13 (Nizhny Novgorod, Russia); among them, there were 3935 men (70%) and 1686 women (30%), their mean age was 61.

Effect of Type 2 Diabetes Mellitus on Five-Year Survival of Patients Hospitalized Because of Acute Decompensated Heart Failure.

Objective: To assess the impact of type 2 diabetes mellitus (T2DM) on prognosis of patients hospitalized because of acute decompensated heart failure (ADHF).

Materials And Methods: We analyzed data of the hospital register of ADHF which comprised information on 735 patients (254 [35%] with T2DM) consecutively admitted in 2010-2011. Median follow-up was 1790 days.

[Effect of Type 2 Diabetes Mellitus on Five‑Year Survival of Patients Hospitalized Because of Acute Decompensated Heart Failure].

Objective: To assess the impact of type 2 diabetes mellitus (T2DM) on prognosis of patients hospitalized because of acute decompensated heart failure (ADHF).

Materials And Methods: We analyzed data of the hospital register of ADHF which comprised information on 735 patients (254 [35%] with T2DM) consecutively admitted in 2010-2011. Median follow‑up was 1790 days.

[Variability of glycemia and ventricular rhythm disturbances in patients with chronic heart failure and type 2 diabetes mellitus].

Aim of this observational study was assessment of effect of variability of glycemia on ventricular ectopic activity in patients with chronic heart failure (CHF) and type 2 diabetes mellitus (n=80). According to study protocol 24-hour Holter ECG monitoring was carried out at baseline, and after 3 and 6 months. Measurements of blood glucose level were made at 8 points during ECG monitoring - before and in 2 hours after main meals, before bedtime and at 3 o'clock in the morning.

[Prognostic value of cardiovascular autonomic neuropathy in patients with combination type 2 diabetes mellitus and chronic heart failure].

Type 2 diabetes mellitus (DM) is often combined with chronic heart failure (CHF). Cardiovascular autonomic neuropathy (CAN) is widely spread complication of DM. In this work we studied effect of CAN on the course of CHF in patients with type 2 DM.

[Chronic heart failure in patients with type-2 diabetes].

Combination of diabetes and chronic heart failure is a frequently occurring syndrome. We studied interrelationship between state of carbohydrate metabolism, diabetic nephropathy and level of natriuretic peptide in patients with type 2 diabetes and concomitant chronic heart failure. The study confirmed high diagnostic value of natriuretic peptide as quantitative criterion of the presence of heart failure and revealed association of decompensation of carbohydrate metabolism and presence of diabetic nephropathy with more severe heart failure and left ventricular dysfunction.