[Role of trace elements in the development of chronic ischemic heart disease].

It was shown that determination of erythrocyte superoxide dismutase activity proves to be the adequate test of antioxidant protection under chronic coronary heart disease as well as the reliable laboratory test for the control of the effect of prophylactic ultra-violet radiation.

[The role of peroxidation processes and antioxidant protection in nitrite-induced hypoxia and its correction with vitamins].

Different doses of sodium nitrite were studied for their action in acute and chronic experiments on rats. Nitrite (NaNO2) hypoxia in rats was simulated to show how the methemoglobin (MtHb) level in blood depends on NaNO2 doses and the method of introduction. Lethal and sublethal doses of NaNO2 (50% of MtHb and more) promoted a decrease of lipid peroxidation (LP) in the liver microsomes, while the average and easy level of hypoxia activated it.

[Vitamin E and its synthetic analogs in experimental cardiovascular pathology].

Oxidative metabolism and the antioxidant system were studied in the myocardium of rats with various experimental impairments of heart tissue. Vitamin E and its synthetic derivatives proved to be effective in correction of the deteriorations observed.

[Indices of structure and function of erythrocyte membranes in rats with vitamin E deficiency and their correction with antioxidant drugs].

It is found that the amount of saturated fatty acids grows, while that of unsaturated--falls in the erythrocyte membranes of rats maintained on a diet without vitamin E. In this case transmembrane calcium transport catalyzed by Ca2(+)-ATPase (EC 3.6.

[The biological role of superoxide dismutase].

Recent data available in literature on mechanisms for regulation of the activity of superoxide dismutase (an antioxidant enzyme) and its interrelation to other enzymes and antioxidants are generalized. The role of superoxide dismutase in the ontogenesis and under different pathologies accompanied by the formation of free radicals is considered.

[Glutathione-S-transferase activity in tissues of rats with cardiovascular pathology].

The activity and certain properties of glutathione-S-transferases from tissues of rats with cardiovascular pathology are studied. Role of the enzyme in the detoxication processes in the myocardium is shown.

[Effect of vitamins A, E and K on the indices of the glutathione antiperoxide system in gingival tissues in periodontosis].

Glutathione reductase is activated and the content of glutathione sulfhydryl groups is increased in the gingival tissue of patients afficted with parodontosis. The degree of alterations depends on the degree of the development and character of the disease. Application of antioxidant vitamin therapy (vitamins A, E and K) locally and per os normalizes the parameters under study and improves the status of the parodontium.

[Activity of enzymes with an antioxidant action in the myocardium and blood of the rat during cardiovascular insufficiency].

It is found that glutathione reductase and superoxidismutase activity decreases in postmitochondrial fraction of the myocardium tissue under cardiovascular insufficiency of the hemodynamic type. In erythrocytes the activity of lipoperoxide-detoxicating glutathione peroxidase--GSH-peroxidase II lowers and that of hydrogen peroxide-utilizing GSH-peroxidase I grows. Disturbances in the antioxidant enzymic systems are discussed for their role in development of cardiac insufficiency.