Publications by authors named "Po-Chuan Hsieh"

Background: Blunt cerebrovascular injury (BCVI) accounts for 1-3 % of patients with blunt trauma, which should be promptly diagnosed and managed due to risk of cerebral infarction and death. Antithrombotic therapy had been proven to reduce risk of stroke and mortality. However, due to concern of hematoma progression, treatment suggestion is still inconclusive for patients with concurrent traumatic intracranial hemorrhage.

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  • - This study explores using the C1 nerve root as a key surgical guide for identifying the shunting point of craniocervical junction spinal dural arteriovenous fistulas (CCJ-SDAVF) during surgery, based on data from 7 patients treated from January 2017 to June 2023.
  • - Of the 7 patients, most (71.4%) were male, and all showed complete obliteration of the CCJ-SDAVFs post-surgery, with follow-up assessments revealing no recurrences within two years.
  • - The findings suggest that interrupting CCJ-SDAVFs surgically yields high success rates and good functional recovery for most patients, emphasizing the importance of identifying the C1 nerve
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  • * Out of 112 patients analyzed, the research found that 13.4% experienced recurrence, predominantly among those treated without stents, and aneurysm rupture was a significant risk factor for recurrence.
  • * The findings revealed that aneurysms treated with stent-assisted coiling had better long-term outcomes, as no re-recurrence was noted in patients undergoing this method after an initial recurrence.
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Objective: Continuous cardiac monitoring on patients with aneurysmal subarachnoid hemorrhage (aSAH) is difficult out of intensive care unit (ICU) in the subacute stage. Therefore, we verified the feasibility of a novel electrocardiography (ECG) patch device to record long-term heart rhythm.

Methods: The ECG patches were applied on aSAH patients during their stay in general ward.

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  • The study investigates delayed progressive mass effect (DPME) following treatment of ruptured middle cerebral artery (MCA) aneurysms, noting its association with poor clinical outcomes and the possible need for additional surgical intervention.
  • Out of 80 patients studied, 27 (33.7%) experienced DPME, which significantly correlated with a higher likelihood of requiring salvage surgery and worse 90-day functional outcomes.
  • Independent risk factors for DPME included the presence of hematomas, CTA spot signs, and low-density areas in the perisylvian region, highlighting the importance of monitoring these factors post-operation.
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Objectives: For the endovascular intervention of acute ischemic stroke, a transcervical route is an alternative approach in patients with challenging anatomical variations. Percutaneous puncture is a common way, but it can cause many fatal complications. Direct carotid artery exposure is an alternative for reducing complications.

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Cerebrospinal fluid (CSF) leakage due to incidental durotomy is an inherent complication of spine surgery. With appropriate treatment, complications of CSF leakage, such as headache and even meningitis, can be reduced. CSF leakage could be detected on the basis of correlated clinical symptoms; diagnosis should be based on these symptoms and appropriate imaging studies.

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Background: Balloon microcatheters are widely used for endovascular treatment. However, no reports on direct coil embolization from dual-lumen balloon microcatheters are available in the literature. This report is the first description of direct coil embolization using this type of balloon microcatheter for looming bleeding emergencies.

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Background: Dual antiplatelet therapy is widely used for stent-assisted coil embolization (SACE) for unruptured intracranial aneurysms (UIAs) to prevent thromboembolic events (TEs). Compared to clopidogrel associated with aspirin, knowledge of the safety and efficacy of ticagrelor is lacking in large studies to date.

Methods: A retrospective cohort study was conducted from January 2016 to December 2018 with at least one year of follow-up in a single institution and systemic review.

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  • - The study aimed to evaluate the effectiveness of swab cultures taken from cryopreserved skull flaps during cranioplasties in predicting surgical site infections (SSIs).
  • - An analysis of 422 patients revealed an overall infection rate of 7.58%, with swab cultures showing high specificity but low sensitivity, resulting in many false-positive and false-negative results.
  • - The findings concluded that swab cultures should not be routinely used during delayed cranioplasties due to their poor accuracy in predicting SSIs and the types of pathogens involved.
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Background: Posterior reversible encephalopathy syndrome (PRES) is considered a benign entity and is usually reversible with only medical management, but persistent neurologic deficits and disability or death can occur without adequate treatment. Favorable outcomes have been associated with surgical decompression in malignant-type PRES in which hemorrhagic transformation or brain stem compression has developed.

Case Description: Here we report a case of malignant PRES in a 61-year-old female of Asian descent in which the disease rapidly progressed to coma and a near-fatal condition with uncal herniation caused by severe brain edema; however, this patient achieved a dramatic recovery without surgical decompression.

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Background: Treatment for circumferential vertebral artery dissecting aneurysms (VADAs) remains challenging. Stent-assisted coil embolization is the most common treatment technique. However, this approach presents high rates of incomplete occlusion and recurrence, often requiring the addition of second or third stents for reconstruction.

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Purpose: Intracranial atherosclerosis disease (ICAD) is an essential cause of stroke. The characteristics of effective treatment include low periprocedural risk and a sustained treatment effect. Angioplasty with a conventional balloon for ICAD is safe but has a dauntingly high restenosis rate.

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Background: Cerebral vasospasm still results in high morbidity and mortality rates in patients after aneurysmal subarachnoid hemorrhage (SAH). The aim of this study was to establish a protocol for the management of vasospasm and demonstrate our experience of angioplasty using the Scepter XC balloon catheter.

Methods: In this retrospective study, a computed tomography angiography and perfusion image was arranged if early symptoms occurred or on the 7th day following aneurysmal SAH.

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Severe neurological complications following infective endocarditis remain a major problem with high mortality rate. The long-term neurological consequences following infective endocarditis remain uncertain. Otherwise, neurosurgeries could be performed after these complications; however, few clinical series have reported the results.

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Background: Proximal anterior cerebral artery (A1) aneurysms are rare among all intracranial aneurysms and are regarded as difficult to treat endovascularly. Treatment is even more challenging in patients with ruptured aneurysms and acute subarachnoid hemorrhage owing to the small size and proximity to perforators. Though challenging, endovascular treatment can provide favorable outcomes in such patients.

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Objective: Cranioplasty is a technically simple procedure intended to repair defects of the skull to provide protection after craniectomy, improve functional outcomes, and restore cosmesis. Several materials have been used for the restoration of skull defects, including autologous bone grafts (AGs), polymethyl methacrylate (PMMA) flaps, and titanium mesh (T-mesh). However, the long-term results of cranioplasty after use of these materials are controversial.

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  • Acquired pial arteriovenous fistula (pAVF) is a rare type of blood vessel abnormality in the brain, and this study reviews existing cases and presents a new one.
  • Researchers studied a case where a pAVF developed after brain surgery, along with a systematic review of similar cases from literature between 1975 and 2018.
  • The findings reveal that acquired pAVFs are typically asymptomatic in adults, tend to show less severe symptoms compared to primary pAVFs, and can be effectively treated with surgery, resulting in excellent outcomes.
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Children with abusive head trauma tend to have worse outcomes than children with accidental head trauma. However, current predictors of poor outcomes for children with abusive head trauma are still limited. We aim to use clinical data to identify early predictors of poor outcome at discharge in children with abusive head trauma.

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Background: Cranioplasty is a relatively simple and straightforward intervention; however, it is associated with a high incidence of postoperative seizures. Postcranioplasty seizures, especially early seizures, are common and associated with poor outcomes and longer hospital stays. Protocols for preventing and managing early seizures have not been well established.

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Objective: Cranioplasty is a relatively simple and less invasive intervention, but it is associated with a high incidence of postoperative seizures. The incidence of, and the risk factors for, such seizures and the effect of prophylactic antiepileptic drugs (AEDs) have not been well studied. The authors' aim was to evaluate the risk factors that predispose patients to postcranioplasty seizures and to examine the role of seizure prophylaxis in cranioplasty.

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  • * The study involved 27 aSAH patients who underwent procedures to relieve ICP, and it analyzed the relationship between ICP levels and cerebral blood flow by measuring capillary filling times before and after draining cerebrospinal fluid (CSF).
  • * Findings showed that lowering ICP through CSF drainage was linked to improved brain blood flow, suggesting a need for better ICP management strategies in aSAH patients to enhance recovery.
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Background: A ruptured vertebral artery dissecting aneurysm (VADA) with a high clinical grade (Hunt and Hess grade 5) has a devastating prognosis. Because of the high rebleeding rate and location, rapid mortality can occur in patients owing to brainstem compression. Adjuvant decompression of the posterior fossa after securing the aneurysm may improve the outcomes of these patients.

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Background: Vasospasm is a major cause of morbidity and mortality in patients after aneurysmal subarachnoid hemorrhage. Early treatment of ruptured aneurysms is advocated; delayed intervention complicates the treatment strategy leading to significant vasospasm and poor prognosis. We report an endovascular protocol for occlusion of the unsecured aneurysm and angioplasty for vasospasm in a single session.

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  • The study investigates how initial imaging findings, specifically the "venous delay" phenomenon on CT angiography, can predict treatment outcomes in patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH).
  • Researchers analyzed data from 148 patients over a 9-year period to determine the correlation between this imaging predictor and functional outcomes measured by the modified Rankin Scale at three months post-treatment.
  • The results indicated that the venous delay had a stronger association with poor outcomes compared to previously recognized predictors, suggesting it could be important for guiding treatment decisions in these patients.
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