Based on plastically compressed cell-seeded collagen gels, we fabricated a small-diameter tubular construct that withstands arterial pressure without prolonged culture in vitro. Specifically, to mimic the microstructure of vascular media, the cell-seeded collagen gel was uniaxially stretched prior to plastic compression to align collagen fibers and hence cells in the gel. The resulting gel sheet was then wrapped around a custom-made multi-layered braided tube to form aligned tubular constructs whereas the gel sheet prepared similarly but without uniaxial stretching formed control constructs.
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
June 2016
The use of vascular grafts to replace damaged native vessels plays a significant role in clinical cardiovascular disease treatment. Comparable mechanical properties of small-diameter vascular grafts to that of native vessels are crucial and challenging. This study examines how different fabrics and yarns influence the mechanical properties of vascular grafts and evaluate the effectiveness of vascular grafts being used as native vessels.
View Article and Find Full Text PDFPurpose: To investigate the effect of auxiliary grooves on resistance to dislodgment of crowns on compromised molar preparations lacking resistance form.
Materials And Methods: Thirty human molar teeth were randomly assigned to three groups of ten, and prepared to a height-to-width ratio of 0.3 with a total convergence of 50 degrees , and 1-mm shoulder margin.