Phytochemical Profiling and Biological Activities of Pericarps and Seeds Reveal the Controversy on "Enucleation" or "Nucleus-Retaining" of Fruits.

The fruits of are used not only as a popular health food to tonify the liver and kidney, but also as staple materials to treat dementia and other age-related diseases. The pharmacological function of fruits with or without seeds is controversial for treating some symptoms in a few herbal prescriptions. However, the related metabolite and pharmacological information between its pericarps and seeds are largely deficient.

Regorafenib combined with programmed cell death-1 inhibitor against refractory colorectal cancer and the platelet-to-lymphocyte ratio's prediction on effectiveness.

Background: The effectiveness of regorafenib plus programmed cell death-1 (PD-1) inhibitor in treating microsatellite stable (MSS) metastatic colorectal cancer (mCRC) remains controversial.

Aim: To investigate the benefits of regorafenib combined with PD-1 inhibitor in treating MSS mCRC and explore indicators predicting response.

Methods: This retrospective study included a total of 30 patients with microsatellite stable metastatic colorectal cancer treated with regorafenib combined with programmed cell death-1 inhibitor at Henan Provincial People's Hospital between December 2018 and December 2020.

Long noncoding RNA PXN-AS1-L promotes the malignancy of nasopharyngeal carcinoma cells via upregulation of SAPCD2.

Accumulating evidences highlight the critical roles of long noncoding RNAs (lncRNAs) in a variety of cancers. LncRNA PXN-AS1-L was previously shown to exert oncogenic roles in hepatocellular carcinoma. However, the expression, role, and molecular mechanism of PXN-AS1-L in nasopharyngeal carcinoma (NPC) malignancy remain unknown.

Experimental Study on Mechanical and Sensing Properties of Smart Composite Prestressed Tendon.

It is typically difficult for engineers to detect the tension force of prestressed tendons in concrete structures. In this study, a smart bar is fabricated by embedding a Fiber Bragg Grating (FBG) in conjunction with its communication fiber into a composite bar surrounded by carbon fibers. Subsequently, a smart composite cable is twisted by using six outer steel wires and the smart bar.

[Influence of Ginkgo biloba extract on proliferation of ACC-2 cell, Survivin and TIP30 gene expression in adenoid cystic carcinoma of lacrimal gland].

Exploring the influence of extract of Ginkgo biloba (EGB) on the proliferation, apoptosis of ACC-2 cell in lacrimal adenoid cystic carcinoma and analyzing the influence of EGB on the gene expression of Survivin and TIP30 based on the levels of the gene and protein. ACC-2 cell in human with ACC of lacrimal gland disposed by EGB of different concentration was in vitro cultured. MTT method was used for cell proliferation detection.

Carbonyl-bis-(triphenyl-phosphane-κP)(η(2)-1-vinyl-pyrrolidin-2-one-κO)ruthenium(0).

The 1-vinyl-pyrrolidin-2-one ligand in the title compound, [Ru(C(6)H(9)NO)(C(18)H(15)P)(2)(CO)], coordinates to the Ru(0) atom with the olefin double bond and the ketone O atom. The Ru(0) atom adopts a distorted trigonal-bipyramidal coordination geometry, with the C O ligand and the ketone O atom occupying the axial positions. The two triphenyl-phosphane ligands are cis to each other.