Publications by authors named "Pnina Hillman"
Article Synopsis
- Skin biopsies were used in a clinical trial to assess the effects of hyperbaric oxygen therapy (HBOT) on aging skin, targeting key aging hallmarks like telomere shortening and senescent cells.
- The study involved 70 participants, with 13 males undergoing skin biopsies before, during, and after a three-month HBOT treatment, showing significant improvements in collagen density, elastic fiber length, and blood vessel count.
- Results suggest that HBOT can effectively improve skin aging by promoting blood vessel growth and reducing senescent cells, marking a significant breakthrough in understanding treatments for aging in humans.
AKAP3 degradation in sperm capacitation is regulated by its tyrosine phosphorylation.
Biochim Biophys Acta
September 2015
Background: The A-kinase anchoring protein (AKAP) family is essential for sperm motility, capacitation and the acrosome reaction. PKA-dependent protein tyrosine phosphorylation occurs in mammalian sperm capacitation including AKAP3. In a recent study, we showed that AKAP3 undergoes degradation under capacitation conditions.
View Article and Find Full Text PDFActivation of sperm EGFR by light irradiation is mediated by reactive oxygen species.
Photochem Photobiol
September 2015
To acquire fertilization competence, spermatozoa must undergo several biochemical and motility changes in the female reproductive tract, collectively called capacitation. Actin polymerization and the development of hyperactivated motility (HAM) are part of the capacitation process. In a recent study, we showed that irradiation of human sperm with visible light stimulates HAM through a mechanism involving reactive-oxygen-species (ROS), Ca(2+) influx, protein kinases A (PKA), and sarcoma protein kinase (Src).
View Article and Find Full Text PDFEjaculated spermatozoa must undergo a series of biochemical modifications called capacitation, prior to fertilization. Protein-kinase A (PKA) mediates sperm capacitation, although its regulation is not fully understood. Sperm contain several A-kinase anchoring proteins (AKAPs), which are scaffold proteins that anchor PKA.
View Article and Find Full Text PDF