[Efficacy of local use of recombinant interferon alpha-2 preparations in combined treatment of recurrent respiratory papillomatosis].

Clinical-immunological examination of 41 patients with recurrent respiratory papillomatosis (RRP) included determination of phenotype CD3, CD4, CD8, CD16, CD25, CD56, HLA-DR in peripheral blood by flow cytofluorimetry, the levels of IFN-gamma, TNF-alpha, GM-CSF, IL-2, IL-4, IL-5, IL-10, IL-12, IL-13 in the laryngeal secretion by multiplex immunoassay. Interferon inhalation therapy was conducted to prevent recurrence in 23 patients after surgical treatment and in 18 patients as monotherapy. The efficacy of the monotherapy was 45.

[Basic principles of immunocorrective therapy in otorhinolaryngology].

The structural and functional basis of ENT mucosa immunity, leading methods of local immunity assessment in ENT pathology are presented. The experience of the chair and clinic of I.P.

[Choice of tools for ambulatory uvulopalatoplasty on the basis of experimental and clinical studies].

We studied interaction of a radiofrequency scalpel and a semiconductor laser with the tissue phantom. The heated part of the phantom can be easily removed and measured for size of the coagulated area. We investigated to what extent the width of the coagulation necrosis along the incision is influenced by the power and speed of each instrument used for incision.

[Role of echography in diagnosis of diseases of cervical lymph nodes].

We studied echograms of lymph nodes and clinically similar tumors of the neck in 194 patients. A complex of echographic signs providing the best diagnostic indicators: a minimal size of the node, volume, maximal to minimal size ratio and form. Accuracy of differential diagnosis of benign and malignant lymphadenopathies was 80.

[Laser surgery of cicatricial laryngeal stenosis].

The authors consider possibility of using surgical lasers for treatment of cicatricial laryngostenosis (CL); present classification of stenoses depending on the causes and location; emphasize advantages of high-energy laser vs conventional methods (reduced blood loss, no need in previous tracheotomy or laryngofissure, minimal reactive changes, rapid epithelization); describe the procedure of laser radiation and its variants depending on tumor location in the larynx.

[Epidemiology and laser correction of chronic diseases observed in snoring and obstructive sleep apnea].

Investigations of snoring have been initiated because snoring is associated with obstructive sleep apnea syndrome (OSAS) and some chronic diseases eventuating in invalidity. Questionnaire survey provided evidence on snoring and OSAS incidence among different age groups of male and female population of St-Petersburg. Associated chronic diseases were also evaluated.

[Low-intensity laser irradiation in otorhinolaryngology].

Low-intensity laser irradiation is a modality widely practiced in otorhinolaryngology. Basing on extensive personal experience and literature data the authors provide ENT specialists with relevant techniques and parameters of the radiation for different otorhinolaryngological diseases.

[Skin tumors of the face: experience in contact laser excision].

A clinical review is provided of 1558 neoplasm cases of facial skin new growth of different origin and site. The technique of YAG-Nd laser in contact mode application is described. Specific postoperative features are correlated with tumor extension, its histological type and site.

[Mechanisms of interactions between different types of nystagmus].

Basing on the original and literature data it is suggested that all types of nystagmus are formed by the same complex system. Under combined stimulation, impulses from the sensory systems are integrated not only in the vestibular nuclei, but also in a series of structures at cortical-subcortical level. The integration proceeds with its own polarity (activating or inhibiting) when a signal alters the ability of a structure to respond to another inputting signal.

High-frequency jet ventilation in endolaryngeal surgery.

Study Objective: To describe the clinical experience with high-frequency jet ventilation (HFJV) of the lungs during endolaryngeal surgery and its effect on acid-base balance and capillary PO2 (PcO2), PCO2, central hemodynamics, and tracheobronchial mucous membrane.

Design: Evaluation of different modalities of HFJV.

Setting: Operating rooms and otolaryngology intensive care unit in a medical institute.

[The function of the oxidant-antioxidant system in patients with laryngeal cancer].

Lipid peroxidation and antioxidant system were studied at hospital admission, on postoperative day 1, 3 weeks and half a year after surgery in 86 patients with different stages of laryngeal cancer. A correlation is stated between lipid peroxidation disturbances and the defects in the protective antioxidant system. Low-frequency laser irradiation of autoblood produced a clinically beneficial effect and stabilized biochemically the relations between lipid peroxidation and antioxidant systems.

[Contact laser surgery in the treatment of laryngeal neoplasms].

YAG-ND laser contact surgery in combination with tracheal puncture jet ventilation of the lungs were used in managing 128 patients with laryngeal cancer (T1-T2) and 129 patients with benign lesions of the larynx. A complete response was achieved in 97.3% of stage I and 94.

[Computed tomography in the diagnosis of postoperative changes of paranasal sinuses].

Basing on the evidence obtained at examinations of 37 patients within 15-year follow-up after surgery on the maxillary and ethmoidal sinuses, the authors analyse potentialities and techniques of computed tomography in diagnosis of the developments in operated on paranasal sinuses. CT demonstrated advantages in examination of paranasal sinus walls and soft tissue alterations in them.