Value of preoperative HE4 as predictor of advanced disease in endometrioid endometrial cancer.

Objective: To explore the predictive value of serum human epididymis protein 4 (HE4) marker in the preoperative prediction of the risk of advanced disease in the endometrioid subtype of endometrial cancer, and its association with poor prognostic factors. In addition, a cut-off value of HE4 was defined to classify patients according to these results.

Methods: Prospective and multicenter cohort analytical pilot study of patients operated for endometrial cancer at the Miguel Servet University Hospital of Zaragoza (Spain) and the Complejo Universitario of León (Spain) from January 2017 to May 2019.

Central Pathology Review in SENTIX, A Prospective Observational International Study on Sentinel Lymph Node Biopsy in Patients with Early-Stage Cervical Cancer (ENGOT-CX2).

The quality of pathological assessment is crucial for the safety of patients with cervical cancer if pelvic lymph node dissection is to be replaced by sentinel lymph node (SLN) biopsy. Central pathology review of SLN pathological ultrastaging was conducted in the prospective SENTIX/European Network of Gynaecological Oncological Trial (ENGOT)-CX2 study. All specimens from at least two patients per site were submitted for the central review.

[Robotic surgery in gynecology: is it the future?].

Gynecologic surgery has been undergone a significant change in the last decade thanks to innovation in health technology. The appearance of the Da Vinci Surgical System has revolutionized the concept of minimally invasive surgery, due to add advantages over conventional laparoscopic surgery, such us three-dimensional vision, wristed forceps and a complete control of the instruments by the surgeon. The evidence published reflects that robotic surgery is preferable to laparotomy and laparoscopic approach, because it is more accurate, versatile, intuitive, and reduces perioperative morbidity.