Publications by authors named "Ploychanok Keawsomnuk"
Article Synopsis
- Nonalcoholic fatty liver disease (NAFLD) starts with fat accumulation in the liver, leading to a more severe condition called nonalcoholic steatohepatitis (NASH) that includes inflammation and fibrosis.
- A new research model called an organ-on-a-chip (OOC) was created using liver cells to replicate NAFLD and study the effects of drug candidates on this disease.
- The study found that drugs like Pioglitazone helped cell viability while elafibranor reduced fat levels but also negatively affected cell health, indicating that this OOC model is useful for testing NAFLD treatments.
Background: Capsaicinoids, such as dihydrocapsaicin (DHC), exert the health-promoting effects of chili peppers on energy metabolism. The metabolic responses to capsaicinoids are primarily mediated through transient receptor potential cation channel subfamily V member 1 (TRPV1). However, the varying contributions of their metabolites to beneficial health outcomes remain unclear.
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