EPIDEMIOLOGIC ACTIVITIES IN THE MODERN CRIMEA: HUMANITARIAN CHALLENGES AND POSSIBLE SOLUTIONS.

Objective: The aim of this article is to determine the current organisational and normative policies in Crimea concerning epidemiology, in conditions of seven years of Russian effective control over the Peninsula and ongoing COVID-19 pandemic.

Patients And Methods: Materials and methods: The authors analysed the normative acts, budget and governing practice regarding to the current challenges for epidemiologic activities in Crimea, issued by international structures, by the Ukrainian bodies and Russian de-facto "authorities", comparing the ongoing situation to the international obligations of both conflicting states.

Conclusion: Conclusions: The research proves that a systematic medical crisis, caused by Russia's efforts aimed at establishment of its own control over Crimea, resulted in new challenges in COVID-19 pandemic conditions.

[Prediction of the efficacy of the non-medicamental treatment with the use of the ensemble of classifiers].

The importance to have the most efficacious tools and methods for the prevention and treatment of various diseases and rehabilitation of the patients dictates the necessity of search for new means of optimal correction of individual reserves of the organism. One of the approaches to addressing this problem is simulation of prognostication of curative effects of non-medicamental therapy. It is proposed to choose the therapeutic program using an ensemble of classifiers.

[A method for predicting the efficiency of rehabilitative treatment based on decision tree analysis].

The necessity of the choice of means and methods to facilitate optimal correction of individual reserves of the organism accounts for the importance of the search for the most efficient preventive, therapeutic, and rehabilitative modalities. One way to address this problem is to simulate prognosis of the outcomes of rehabilitative treatment. It is proposed to use a two-step method to achieve this goal.

[Genomic polymorphism of the main subspecies of the plague agent strains].

Genomic fingerprinting analysis of plague agent strains of the main subspecies isolated in natural foci of various types in the Russian Federation and neighboring countries suggests their genetic polymorphism, while they are similar in phenotypic properties. The strains of the main subspecies, Y. pesis subsp.

[Comparative study of the diagnostic value of new cholera eltor bacteriophages ctx+, ctx-, and KhDF-3, 4, and 5].

The comparative evaluation of the diagnostic value of new cholera eltor bacteriophages ctx+ and ctx-, as well as monophages X[symbol: see text]-3, 4, 5, demonstrated their high activity and specificity. Using of these bacteriophages epidemic potential of 95% Vibrio cholerae eltor strains ctx+ and 84.5% of V.

[Genotyping Yersinia pestis strains from various natural foci].

Seven genetic variants of Yersinia pestis were detected by finger-printing of 85 strains of this bacterium from natural foci by means of a BX probe. Variants of Y. pestis strains correlate with certain species of carriers.

[The comparative characteristics of the pathogenic action of Vibrio cholerae of the non-O1 group O139 serovar and of the O1 group on the intestinal APUD system of suckling rabbits].

The comparative study of the enteropathogenic action of V. cholerae strains of group non-O1, serovar O139, and group O1 with different virulence on the APUD system of the intestine of suckling rabbits after intraenteral infection revealed that V. cholerae of group non-O1 induced inflammatory changes in the intestine and the pronounced toxic lesion of parenchymal organs.

[Comparative study of the structure of some genetic probes used for typing Yersinia pestis strains].

A nucleotide sequence common for genetic probes used for detection and investigation of Y. pestis strains MK, IS100, and HRSIII was identified on the basis of restriction, hybridization, and computer analysis. This region of chromosomal DNA is a part of low-molecular BX-probe (about 170 bp) we have developed.

[An immunoenzyme test system for the identification of typical and atypical strains of the plague microbe].

The authors have developed the optimal variant of the enzyme immunoassay system that contains plague murine monoclonal and equine polyclonal immunoglobulins and identified all plague microbe strains at a high sensitivity (3.84 m.cl/ml).

[Effect of plague microbe fraction 1 protein-polysaccharide complex and pure protein on metabolic parameters of macrophages].

The investigation reveals different influence of the plague microbe's fraction 1 polysaccharide-protein complex and of it's purified protein on the 5'-nucleotidase activity and on the chemiluminescence response of peritoneal macrophages. Both of these metabolic indexes were found to be dependent on the dose of fraction 1 and duration of time till examination.

[Relationship of the structure of cellulose and certain model compounds to the dynamics of molecular reactions].

Using the results of kinetic studies of free radical recombination in cellulose and in some model compounds, some data as to their structure were obtained. Cellulose is characterized by the distribution function of microregions with different energy of molecular interaction. The minimal value of activation energy of macromolecule movement is 37-42 kJ/mol (1.