[The morphofunctional prerequisites for the development of exudative otitis media in the children presenting with chronic adenoiditis].

The objective of the present study was to elucidate the structural and functional mechanisms underlying disturbances of the protective nasolaryngeal barrier with special reference to the following histological and immunohistochemical characteristics of the pharyngeal tonsils (CD4, CD20, CD68, IgA, P53, BCL2, Ki67, TGF-beta) in the children aged 3-6 years and presenting with complicated (n=20) or uncomplicated (n=20) chronic adenoiditis (CA). It was shown that adenoids of the patients with complicated chronic adenoiditis less frequently exhibit markers of active inflammation, such as hyperemia, intraepithelial infiltration, and hemosiderophages. Also, they have the smaller mean area of lymphoid follicles and the number of functional intrafollicular macrophages suggesting impaired immunological reactivity.

[Gastrointestinal hemorrhage in cardiosurgery in patients with endothelial dysfunction].

Aim: To estimate the prognostic value of the hypoxic test, intragastric pH-metry, and endothelial dysfunction in cardiosurgical patients at risk of gastrointestinal hemorrhage.

Materials And Methods: This prospective study approved by the ethical committee was performed based at the Department of Anesthesiology and Resuscitation, Research Institute of Cardiology, Tomsk, in 2012-2013. It included 30 patients who had previously undergone myocardial revascularization with artificial circulation.

[Cytomorphological analysis of remodeling of the bronchial wall in different types of bronchial asthma].

The objective of the present work was to search for the tissue and cellular markers of remodeling of bronchial mucosa in the patients with different clinical forms of bronchial asthma (BA). The use of up-to-date morphometric techniques has demonstrated that mild and moderately severe forms of bronchial asthma are accompanied by the development of Th2-immune response associated with increased production of interleukin-4 and marked degranulation of eosinophilic granulocytes resulting in desquamation of epithelium and goblet cell hyperplasia. The severe BA phenotype of "chronic asthma with fixed obstruction" is associated with the development of non-atopic inflammation in the bronchial mucous membrane that manifests itself as the increased concentration of interleukin-8 in bronchial mucosa and its neutrophilic infiltration leading to the development of pronounced subepithelial fibrosis, thickening of the basal membrane, and atrophy of epithelium.

[Characteristic of inflammatory infiltrate of gastric mucosa in patients with grade II-III gastric dysplasia and of stomach cancer].

The study included 85 inpatients and outpatients in whom composition of inflammatory infiltrate from gastric mucosa (GM) was determined at the Oncological Research Institute, Tomsk Research Centre of the Siberian Division, Russian Academy of Medical Sciences. The patients were allocated to 4 groups depending on nosological form of the disease. Group 1 comprised 21 patients with grade II-III GM epithelial dysplasia, group 2 - 24 patients having stomach cancer (histologically confirmed adenocarcinoma), group 3 - 19 patients with stage II-III mucinous gastric carcinoma, group 4 - 20 allegedly healthy subjects without signs of gastrointestinal pathology.

[Pathomorphological characteristics of unstable bronchial asthma (brittle phenotype)].

Aim: To ascertain morphological features of severe uncontrolled bronchial asthma (BA) of brittle phenotype.

Material And Methods: Standard bronchofibroscopy was made in 10 patients with severe BA (brittle phenotype) and 9 patients with moderate BA. Cell composition of bronchial lavage and morphological indices of bronchial mucosa biopsies were studied.

[Erosive lesions in the gastroduodenal zone of patients with bronchial asthma].

The purpose of the investigation was to study the frequency and clinicomorphological features of erosive lesions (EL) in the gastroduodenal zone (GDZ) of patients with bronchial asthma (BA). One hundred and sixty-three patients suffering from allergic BA of different degrees of severity were examined. The examination included clinical evaluation of the GDZ, esophagogastroduodenoscopy with gastric and duodenal mucosal biopsy, and subsequent analysis of the biopsy samples using histological, histochemical, morphometric methods, and electron microscopy.

[Peculiarities of duodenal ulcer with concomitant bronchial asthma (clinical and pathomorphological aspects)].

Aim: To study incidence of gastroduodenal ulcer (GDU) in bronchial asthma and clinicomorphological features of ulcer disease in BA in long-term use of systemic corticosteroids (SCS) and without SCS.

Material And Methods: The trial covered 297 BA patients. They have undergone clinicoendoscopic examination of the gastroduodenal zone (GDZ) for duodenal ulcer with assessment of clinical gastroenterological symptoms and morphological analysis of biopsies of gastric and duodenal mucosa using histological, histochemical and morphometric methods.

Comparative study of eosinophils in the blood and induced sputum during bronchial asthma.

Eosinophilia characterized by accumulation of low-density eosinophils and high functional activity of normal-density eosinophils was detected in the blood from patients with bronchial asthma. Low-density eosinophils are characterized by low content of granules. In patients with bronchial asthma morphological and functional characteristics of bronchial eosinophils were similar to those of blood low-density eosinophils.

[Impact of long-term systemic glucocorticoid therapy for bronchial asthma on the occurrence and course of peptic ulcer].

The study was undertaken to examine the incidence and specific features of peptic ulcer (PU) of the gastroduodenal area (GDA) in bronchial asthma (BA) and the impact of long-term oral maintenance therapy with systemic glucocorticosteroids (GCS) on the occurrence and course of peptic ulcer. Among the 260 examined patients with BA, GDA PU was revealed in 70(26.9%).

[Status of nucleoprotein synthesis in hematopoietic organs in mice with primary hypothyroidism].

A rate of incorporation of 3H-thymidine, 3H-uridine and 14C-glycine into the nucleoproteins of bone marrow, spleen, thymus and ileocecal lymph nodes was studied in BALB/c mice with hypothyrosis developed after administration of 1% KClO4 within a month. Distinct hypoplasia of bone marrow and spleen was found in the experimental animals; the synthesis of nucleoproteins was most impaired in bone marrow. The dependence of hemopoietic tissues on thyroid hormones was decreased as follows: bone marrow > spleen > thymus > lymph node.