Discrete model for laser driven etching and microstructuring of metallic surfaces.

We present a unidimensional discrete solid-on-solid model evolving in time using a kinetic Monte Carlo method to simulate microstructuring of kerfs on metallic surfaces by means of laser-induced jet-chemical etching. The precise control of the passivation layer achieved by this technique is responsible for the high resolution of the structures. However, within a certain range of experimental parameters, the microstructuring of kerfs on stainless steel surfaces with a solution of H3PO4 shows periodic ripples, which are considered to originate from intrinsic dynamics.

Herbicidal cyanoacrylates with antimicrotubule mechanism of action.

The herbicidal mode of action of the new synthetic cyanoacrylates ethyl (2Z)-3-amino-2-cyano-4-ethylhex-2-enoate (CA1) and its isopropyl ester derivative CA2 was investigated. For initial characterization, a series of bioassays was used indicating a mode of action similar to that of mitotic disrupter herbicides such as the dinitroaniline pendimethalin. Cytochemical fluorescence studies including monoclonal antibodies against polymerized and depolymerized tubulin and a cellulose-binding domain of a bacterial cellulase conjugated to a fluorescent dye were applied to elucidate effects on cell division processes including mitosis and microtubule and cell wall formation in maize roots.

Financing biotechnology projects: lender due diligence requirements and the role of independent technical consultants.

An increasing number of biotechnology projects are being brought to commercialization using conventional structured finance sources, which have traditionally only been available to proven technologies and primary industries. Attracting and securing competitive cost financing from mainstream lenders, however, will require the sponsor of a new technology or process to undergo a greater level of due diligence. The specific areas and intensity of investigation, which are typically required by lenders in order to secure long-term financing for biotechnology-based manufacturing systems, is reviewed.

Ear damage caused by leisure noise.

Noise is a health risk. Recent findings suggest that leisure noise is a substantial danger especially to children, teenagers and young adults. Epidemiological studies of teenagers with no occupational noise exposure show an increasing number with a substantial and measurable irreversible inner ear damage.

Triaziflam and Diaminotriazine derivatives affect enantioselectively multiple herbicide target sites.

Enantiomers of triaziflam and structurally related diaminotriazines were synthesized and their herbicidal mode of action was investigated. The compounds caused light and dark-dependent effects in multiple test systems including heterotrophic cleaver and photoautotrophic algal cell suspensions, the Hill reaction of isolated thylakoids and germinating cress seeds. Dose-response experiments revealed that the (S)-enantiomers of the compounds preferentially inhibited photosystem II electron transport (PET) and algae growth with efficacies similar to that of the herbicide atrazine.

[Hearing loss caused by leisure noise].

Although noise in general can induce hearing loss, environmental noise represents an important risk for children, teenagers and young adults. Epidemiological investigations now support the occurrence of an increasing number of irreversible hearing losses in these groups. Major causes of hearing loss are toys (guns), explosives and electroacoustically amplified music delivered by head sets or heard in discotheques and open air concerts.

[Comments on the revision of the Königstein instructional pamphlet].

The "Königsteiner Merkblatt (juris prudence)" is an instructional booklet of the general association of juris prudence involves accident insurance ("Hauptverband der gewerblichen Berufsgenossenschaften") in Germany. Medico-legal examinations of occupational noise-induced hearing loss are detailed. In contrast to prior editions, the 4th edition of this booklet, published in January 1996, has been extended by the definitions of legal regulations important for the physician in making medical decisions.

[Hearing loss caused by leisure activity-induced noise].

The number of persons with hearing disability in most countries is more than 10%. In developing countries of the third world, inflammations are the most important cause of hearing dysfunction, but in more civilized countries, more and more individuals are injured by a noisy environment and by noise that is individually produced. In this way, a great number of young people acquire defects of hearing which are not reparable.

Maturational aspects of the human auditory pathway: anatomical and electrophysiological findings.

Anatomical investigations were carried out on 39 human brains ranging in age from the 29th week of development to the 70th year of life. It was demonstrated that myelination, as a prerequisite for functional maturation, takes place during the 1st year of life. Functional maturation was analyzed with electrophysiological techniques.

Cell movement and shape are non-random and determined by intracellular, oscillatory rotating waves in Dictyostelium amoebae.

We present evidence for a mechanism of eukaryotic cell movement. The pseudopodial dynamics and shape of Dictyostelium discoideum amoebae were investigated using computer-supported video microscopy. An examination of the cell periphery by the novel method of serial circular maps revealed explicit, classical wave patterns, which indicate the existence of intrinsic intracellular oscillations.

The locomotion, shape and pseudopodial dynamics of unstimulated Dictyostelium cells are not random.

The dynamic periphery of unstimulated, preaggregation, hunger-stage Dictyostelium discoideum amoebae was investigated by time-lapse videomicroscopy and digital image processing. Circular maps (i.e.

[Early detection of hearing disorders. 10 years experience with screening more than 8,000 infants].

Prevention and early detection of deficits of the developing human being demand more and more complex solutions. Screening programmes have been developed to detect deficits and diseases before they cause symptoms. A well-organised and accurately performed screening programme can detect preliminary signs of diseases and may prevent irreversible damage.

[Expert assessment of hearing loss within the scope of the social compensation law and the law regarding severely handicapped patients].

Special problems are described concerning expert opinions on hearing disability and hearing loss with regard to the German Social Rights for Compensation and the laws for handicapped persons. In some aspects there are similarities to the rights of accident insurance, but disability programs question only the degree of handicap present and not the source of the hearing loss. The expert opinion on the subject's ability to work in his or any other profession must only determine the patient's ability to hear and the tasks needed to fulfill the profession.