Publications by authors named "Plat V"

Introduction: Implant loss following implant-based breast reconstruction (IBBR) is a serious complication, resulting in re-operations, patient suffering, and a significant decrease in quality of life. This study aimed to create a validated risk prediction model for implant loss after IBBR using perioperative risk factors.

Methods: Patients who had undergone either a two-stage or a direct-to-implant postmastectomy IBBR were identified from the Dutch Breast Implant Registry (DBIR).

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Background: Breast cancer is the most common cancer in women, and breast reconstruction improves the patient's quality of life. Autologous breast reconstruction provides benefits of natural appearance, feel, and long-term results without implant-associated problems. However, thin patients are not always suitable for standard autologous reconstructions.

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This review provides an overview regarding the abdominal effects of an omentectomy, with or without extra-peritoneal reconstructions. In general, reported complication rates were low. Short-term complications involved ileus, bowel stenosis, abdominal abscess and sepsis (range 0.

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Article Synopsis
  • This study investigated how different grades of tumor response (TRG) and a new scoring system (TRG-ypN) relate to cancer recurrence and survival in patients with esophageal adenocarcinoma after treatment.
  • The research, which included 2,746 patients treated between 2007 and 2016, found that lower TRG scores corresponded to lower recurrence rates and longer overall survival, with TRG1 patients having better outcomes than those with higher scores.
  • Additionally, residual nodal disease had a more significant negative impact on prognosis compared to remaining disease at the primary tumor site, highlighting the importance of nodal status in treatment outcomes.
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Background: Recurrence is frequently observed after esophageal cancer surgery, with dismal post-recurrence survival. Neoadjuvant chemoradiotherapy followed by esophagectomy is the gold standard for resectable esophageal tumors in the Netherlands. This study investigated the recurrence patterns and survival after multimodal therapy.

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Introduction: Implant loss following breast reconstruction is a devastating complication, which should be prevented as much as possible. This study aimed to validate a previously developed multicenter risk model for implant loss after implant-based breast reconstructions, using national data from the Dutch Breast Implant Registry (DBIR).

Methods: The validation cohort consisted of patients who underwent a mastectomy followed by either a direct-to-implant (DTI) or two-stage breast reconstruction between September 2017 and January 2021 registered in the DBIR.

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Objective: This study investigated the patterns, predictors, and survival of recurrent disease following esophageal cancer surgery.

Background: Survival of recurrent esophageal cancer is usually poor, with limited prospects of remission.

Methods: This nationwide cohort study included patients with distal esophageal and gastroesophageal junction adenocarcinoma and squamous cell carcinoma after curatively intended esophagectomy in 2007 to 2016 (follow-up until January 2020).

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Article Synopsis
  • Transthoracic esophagectomy (TTE) can help with mediastinal dissection in esophageal cancer treatment but may lead to worse cardiopulmonary outcomes, especially in high-risk patients, who might be better suited for transhiatal esophagectomy (THE).
  • A study of 5,438 patients from the Dutch Upper GI Cancer Audit evaluated the short-term outcomes of TTE versus THE among high-risk individuals, categorizing them based on the Charlson comorbidity index.
  • Results showed that high-risk patients experienced significantly higher mortality and complications after TTE compared to THE, particularly with cervical reconstructions, suggesting that surgical approach should consider the patient's comorbidity profile to avoid complications.
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Background: Somatostatin analogues (SA) are currently used to prevent postoperative pancreatic fistula (POPF) development. However, its use is controversial. This study investigated the effect of different SA protocols on the incidence of POPF after pancreatoduodenectomy in a nationwide population.

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Article Synopsis
  • This study analyzed trends in the treatment and outcomes for patients with distal esophageal and gastro-esophageal junction cancers in the Netherlands from 2007 to 2016.
  • It found that the use of transthoracic esophagectomy, neo-adjuvant treatments, and minimally invasive surgery significantly increased during this period.
  • Postoperative results improved, with lower complication rates, higher success in tumor removal, better lymph node retrieval, and longer survival times for patients.
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Background: The role of esophageal microbiota in esophageal cancer treatment is gaining renewed interest, largely driven by novel DNA-based microbiota analysis techniques. The aim of this systematic review is to provide an overview of current literature on the possible association between esophageal microbiota and outcome of esophageal cancer treatment, including tumor response to (neo)adjuvant chemo(radio)therapy, short-term surgery-related complications, and long-term oncological outcome.

Methods: A systematic review of literature was performed, bibliographic databases were searched and relevant articles were selected by two independent researchers.

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Purpose: The number of bariatric procedures has increased exponentially over the last 20 years. On the background of ever-increasing incidence of esophageal malignancies, the altered anatomy after bariatric surgery poses challenges in treatment of these cancers. In this study, an epidemiological estimate is presented for the future magnitude of this problem and treatment options are described in a retrospective multicenter cohort.

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Unlabelled: Implant loss is the most severe complication of implant-based breast reconstructions. This study aimed to evaluate the incidence of implant loss and other complications, identify associated risk factors, and create a risk model for implant loss.

Methods: This was a retrospective cohort study of all patients who underwent a mastectomy, followed by either a two-stage or a direct-to-implant breast reconstruction.

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Background: Infectious complications are frequently encountered after abdominal surgery. Early recognition, diagnosis, and subsequent timely treatment is the single most important denominator of postoperative outcome. This study prospectively addressed the predictive value of routine assessment of C-reactive protein levels as an early marker for infectious complications after major abdominal surgery.

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Background: CT imaging is the primary diagnostic approach to assess the integrity of the intrathoracic anastomosis following Ivor Lewis esophagectomy. In the postoperative setting interpretation of CT findings, such as air and fluid collections, may be challenging. Establishment of a scoring system that incorporates CT findings to diagnose anastomotic leakage could assist radiologists and surgeons in the postoperative phase.

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Background: Anastomotic leakage (AL) remains a severe complication following colorectal surgery, having a negative impact on both short- and long-term outcomes. Since timely detection could enable early intervention, there is a need for the development of novel and accurate, preferably, non-invasive markers. The aim of this study was to investigate whether urinary intestinal fatty acid binding protein (I-FABP) could serve as such a marker.

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Background: Robot-assisted surgery for esophageal cancer is increasingly applied. Despite this upsurge, the preferential technique to create a robot-assisted intrathoracic anastomosis has not been established.

Data Sources: Bibliographic databases were searched to identify studies that performed a robot-assisted Ivor Lewis esophagectomy and described the technical details of the anastomotic technique.

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Aim: Inflammatory markers such as serum C-reactive protein (CRP) are used as routine markers to detect anastomotic leakage following colorectal surgery. However, CRP is characterized by a relatively low predictive value, emphasizing the need for the development of novel diagnostic approaches. Volatile organic compounds (VOCs) are gaseous metabolic products deriving from all conceivable bodily excrements and reflect (alterations in) the patient's physical status.

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Background: Esophageal cancer is surgically treated by means of an esophagectomy. However, esophagectomies are associated with high morbidity rates with dehiscence of the anastomosis occurring in 19% of these procedures in the Netherlands. Application of a fibrin sealant may improve mechanical strength of the anastomosis.

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Background: Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with tumors of the esophagus or pancreatic head. Postoperative mortality is strongly correlated with the occurrence of anastomotic leakage (AL). Delay in diagnosis leads to delay in treatment, which ratifies the need for development of novel and accurate non-invasive diagnostic tests for detection of AL.

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Background: Esophageal anastomotic leakage (EAL) is a severe complication following gastric and esophageal surgery for cancer. Several non-modifiable, patient or surgery related risk factors for EAL have been identified, however, the contribution of modifiable intraoperative parameters remains undetermined. This review provides an overview of current literature on potentially modifiable intraoperative risk factors for EAL.

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