Design, implementation, and characterization of a kinematically aligned, cascaded spot- array generator for a modulator-based free-space optical interconnect.

The design and the implementation of a modular spot-array generator for a modulator-based free-space optical interconnect is presented. Two cascaded diffractive optical elements produce 4 x 8 clusters on a 1600 microm x 800 microm pitch, where each cluster is a 4 x 4 array of (1/e(2)) 13.1-microm-radius spots on a 90-microm pitch.

Interconnection of a two-dimensional array of vertical-cavity surface-emitting lasers to a receiver array by means of a fiber image guide.

The implementation of a 10-channel parallel optical interconnect consisting of a two-dimensional array of vertical-cavity surface-emitting lasers, a 1.35-m fiber image guide, and a metal-semiconductor-metal receiver array is described. Transmission rates of 250 Mbits/s per channel are demonstrated with an optical cross talk of less than -27 dB and a loss of -3 dB.

Design and operation of an in situ microchannel alignment-detection system.

The design of an alignment-detection system that uses off-axis diffractive elements and photodetectors is presented. The system was developed to detect the real-time misalignment of an array of optical beams as they pass through a microchannel relay. The design of this scheme is presented along with experimental results obtained from a prototype detection system.

Design, implementation, and characterization of a hybrid optical interconnect for a four-stage free-space optical backplane demonstrator.

A four-stage unidirectional ring free-space optical interconnect system was designed, analyzed, implemented, and characterized. The optical system was used within a complementary metal-oxide semiconductor-self-electro-optic-effect-device-based optical backplane demonstrator that was designed to fit into a standard VME chassis. This optical interconnect was a hybrid microlens-macrolens system, in which the microlens relays were arranged in a maximum lens-to-waist configuration to route the optical beams from the optical power supply to the transceiver arrays, while the macrolens optical relays were arranged in a telecentric configuration to route optical signal beams from stage to stage.

In situ Interferometric alignment systems for the assembly of microchannel relay systems.

An interferometric alignment technique developed for the assembly of microchannel relay systems is described. The method uses pairs of diffractive lenslets that are arranged to form compact in situ interferometers. The relative transverse, longitudinal, and rotational alignment of the two lenslet arrays can be quantitatively determined from the resulting interference patterns.

Design, implementation, and characterization of an optical power supply spot-array generator for a four-stage free-space optical backplane.

The design and implementation of a robust, scalable, and modular optical power supply spot-array generator for a modulator-based free-space optical backplane demonstrator is presented. Four arrays of 8 x 4 spots with 6.47-mum radii (at 1/e(2) points) pitched at 125 mum in the vertical direction and 250 mum in the horizontal were required to provide the light for the optical interconnect.

Optomechanics for a four-stage hybrid-self-electro-optic-device-based free-space optical backplane.

We present the design, fabrication, and testing of optomechanics for a free-space optical backplane mounted in a standard 6U VME backplane chassis. The optomechanics implement an optical interconnect consisting of lenslet-to-lenslet, as well as conventional lens-to-lens, links. Mechanical, optical, electrical, thermal, material, and fabrication constraints are studied.

Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development.

Rheumatoid arthritis (RA) is a complex genetic disorder in which the HLA-region contributes most to the genetic risk. HLA-DRB1-molecules containing the amino acid sequence DERAA (i.e.

Transfer matrix analysis of the unidirectional grating-assisted codirectional coupler.

The unidirectional grating-assisted codirectional coupler (U-GACC) has recently been proposed. This unique structure permits irreversible coupling between orthogonal waveguide eigenmodes by means of simultaneous modulation of both the real and imaginary parts of the refractive index in the coupling region. Analysis of the U-GACC has until now relied on coupled mode theory, which can be restrictive in its application as a design tool.

Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis.

Objective: Psoriasis of early onset (type I; age of onset
Methods: In a case-control association study, HLA-Cw*06 phenotype frequencies were compared between patients with PsA (n = 480), psoriasis alone (n = 611) and healthy controls (n = 166).

DBR, Sub-wavelength grating, and Photonic crystal slab Fabry-Perot cavity design using phase analysis by FDTD.

We demonstrate a Finite-Difference Time-Domain (FDTD) phase methodology to estimate resonant wavelengths in Fabry-Perot (FP) cavity structures. We validate the phase method in a conventional Vertical-Cavity Surface-Emitting Laser (VCSEL) structure using a transfer-matrix method, and compare results with a FDTD reflectance method. We extend this approach to a Sub-Wavelength Grating (SWG) and a Photonic Crystal (Phc) slab, either of which may replace one of the Distributed Bragg Reflectors (DBRs) in the VCSEL, and predict resonant conditions with varying lithographic parameters.

Time to share. Interview by Adele Waters.

The RCN's Nutrition now campaign, supported by Nursing Standard, is giving nurses the resources to stop patients becoming dehydrated and malnourished.

Reprogrammable optical phase array.

A novel reprogrammable optical phase array (ROPA) device is presented as a reconfigurable electro-optic element. One specific application of the ROPA, a 1 x 6 electro-optic space switch, is fully described. Switching angles are within 2 degrees , and switching is achieved through a complementary metal-oxide semiconductor (CMOS) controlled, diffraction based, optical phase array in a bulk BaTiO3 crystal.

Bulk electro-optic deflector-based switches.

We propose two novel electro-optic (EO) deflectors based on two new nonrectangular geometries: the parabolic and the half-horn configurations. These devices not only provide excellent deflection angles, but also have the potential to build nonblocking 2 x 2 optical switches. A deflector figure of merit is defined, and comparisons with existing EO deflectors are given.

Diffusion of methanol in zeolite NaY: a molecular dynamics study.

Molecular dynamics simulations were performed in order to obtain a detailed understanding of the self-diffusion mechanisms of methanol in the zeolite NaY system. We derived a new force-field term to describe the interactions between the methanol molecules and the extraframework cations. From the simulations, we show that diffusive behavior in the high-temperature range consists of a combination of both short- and long-range motions at low and intermediate loadings.

Cation occupancies in Mg, Co, Ni, Zn, Al ferrite spinels: a multi-element EXAFS study.

The distribution of cations between tetrahedral (A) sites and octahedral (B) sites in ferrite spinels has been studied using K-edge x-ray absorption spectroscopy. The samples include natural and synthetic end-member magnetites (Fe₃O₄), a natural Mn- and Zn-rich magnetite (franklinite) and synthetic binary, ternary and quaternary ferrites of stoichiometry M(²+)M₂(³+)O₄, where M(²+) = Mg, Co, Ni, Zn and M(³+) = Fe, Al. XAS data were obtained for all metals.

Temporal differentiation of optical signals using a phase-shifted fiber Bragg grating.

We propose and experimentally demonstrate an all-optical (all-fiber) temporal differentiator based on a simple pi-phase-shifted fiber Bragg grating operated in reflection. The proposed device can calculate the first time derivative of the complex field of an arbitrary narrowband optical waveform with a very high accuracy and efficiency. Specifically, the experimental fiber grating differentiator reported here offers an operation bandwidth of approximately 12 GHz.

High-throughput screening of RNA polymerase inhibitors using a fluorescent UTP analog.

RNA polymerase (RNAP) is a well-validated target for the development of antibacterial and antituberculosis agents. Because the purification of large quantities of native RNA polymerase from pathogenic mycobacteria is hazardous and cumbersome, the primary screening was carried out using Escherichia coli RNAP. The authors have developed a high-throughput screening (HTS) assay to screen for novel inhibitors of RNAP.

The CX3CL1-CX3CR1 system and psoriasis.

CX3CL1 is a chemoattractant and adhesion molecule that induces the redistribution of CX3CR1-positive inflammatory leucocytes to sites of inflammation. As a consequence of their increased expression in plaques of psoriasis, and location within genomic regions previously linked to this disease, CX3CL1, and its receptor CX3CR1, represent attractive positional and functional 'psoriasis susceptibility genes'. To investigate the CX3CL1-CX3CR1 system in psoriasis, eight single nucleotide polymorphisms (SNPs) in CX3CL1 and two SNPs in CX3CR1 were genotyped in 281 psoriasis patients and 184 unrelated controls.

Cation migration upon adsorption of methanol in NaY and NaX faujasite systems: a molecular dynamics approach.

Molecular dynamics simulations have been carried out to address the question of cation migration upon adsorption of methanol in NaY and NaX faujasite systems as a function of the loading. For NaY, it has been shown that, at low and intermediate loadings, SII cations can migrate toward the center of the supercage due to strong interactions with the adsorbates, followed by a hopping of SI' from the sodalite cage into the supercage to fill the vacant SII site. A SI' cation can also migrate across the double six ring and takes a SI' vacant position.

Modeling the concentration dependence of the methanol self-diffusivity in faujasite systems: comparison with the liquid phase.

Molecular dynamics simulations were performed to understand further the concentration dependence of the self-diffusion of methanol in the faujasite zeolite systems. The evolution of the self-diffusivity was investigated as a function of coverage for DAY and NaY systems to study the effect of both the pore confinement and the presence of the extraframework cations within the supercage. It was found that the self-diffusivity decreases with loading for DAY, whereas for NaY it passes through a maximum at intermediate coverage, in agreement with pulse-field gradient NMR and quasi elastic neutron scattering data reported in similar systems.

Notexin causes greater myotoxic damage and slower functional repair in mouse skeletal muscles than bupivacaine.

Although the myotoxins bupivacaine and notexin are employed for studying processes that regulate muscle regeneration after injury, no studies have compared their efficacy in causing muscle damage or assessing functional regeneration in mouse skeletal muscles. Bupivacaine causes extensive injury in rat muscles but its effects on mouse muscles are variable. We compared functional and morphological properties of regenerating mouse extensor digitorum longus (EDL) muscles after notexin or bupivacaine injection and tested the hypothesis that muscle damage would be more extensive and functional repair less complete after notexin injection.

Molecular dynamics simulation of the cation motion upon adsorption of CO2 in Faujasite zeolite systems.

Molecular Dynamics simulations have been carried out in NaX and NaY Faujasite systems to deepen understanding of the cation rearrangement during the CO2 adsorption process suggested by our recent diffusivity measurements. This study is a major contribution since the rearrangement of the cations in Faujasite, the most promising adsorbent for CO2 storage, can represent a significant breakthrough in understanding the adsorption and diffusion processes at the mircroscopic scale. For NaY, it has been shown that at low and intermediate loadings, SII cations can migrate toward the center of the supercage due to strong interactions with the adsorbates, followed by a hopping of SI'cation from the sodalite cage into the supercage to fill the vacant SII site.

Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice.

Utrophin expression is regulated by calcineurin and up-regulating utrophin can decrease the susceptibility of dystrophic skeletal muscle to contraction-induced injury. We overexpressed the constitutively active calcineurin-A alpha in skeletal muscle of mdx dystrophic mice (mdx CnA*) and examined the tibialis anterior muscle to determine whether the presence of activated calcineurin promotes resistance to muscle damage after lengthening contractions. Two stretches (10 s apart) of 40% strain relative to muscle fibre length were initiated from the plateau of a maximal isometric tetanic contraction.