Publications by authors named "Plamena Ermencheva"
Article Synopsis
- Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation in joints and can lead to a decline in mobility and overall quality of life, but the exact cause remains unclear.
- Genetic, environmental, and lifestyle factors contribute to susceptibility to RA, with certain genetic markers indicating a higher risk for developing the disease.
- Recent studies highlight the significance of the microbiome in influencing immune responses, where changes in microbial composition (dysbiosis) may trigger chronic inflammation and play a crucial role in the development and progression of RA.
Systemic necrotising vasculitides (SNVs) pose significant challenges due to their diverse clinical manifestations and variable outcomes. Therefore, identifying reliable biomarkers holds promise for improving precision medicine in SNVs. This review explores emerging biomarkers aiming to enhance diagnostic accuracy, prognostic assessment, and disease monitoring.
View Article and Find Full Text PDFThe knee is the joint most frequently involved in osteoarthritis, a common joint disorder in the adult population that is associated with significant chronic joint pain, reduced mobility and quality of life. Recent studies have established an association between obesity and the development of knee osteoarthritis that goes beyond the increased mechanical load on the knees as weight-bearing joints. This link is based on the maintenance of a chronic low-grade inflammation, altered secretion of adipokines by the adipose tissue and development of sarcopenia.
View Article and Find Full Text PDF