Publications by authors named "Plamen T Todorov"

We present a Polymyalgia Rheumatica (PMR) case with active Cervical Interspinous Bursitis (CIB) causing debilitat-ing neck pain as the most intensive symptom of the disease as reported by the patient. CIB was diagnosed and followed by Musculoskeletal Ultrasound (MSUS). MSUS examination of patient's posterior cervical region reviled well demarcated an-/ hypoechoic lesions around and cranially of the spinous processes of the sixth and seventh cervical vertebra.

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Aim: To describe the sonoanatomy of the long posterior sacroiliac ligament (LPSL) in healthy volunteers and to assess by ultrasound the LPSL in patients with noninflammatory sacroiliac joint pain (SIP).

Material And Methods: We assessed 64 LPSLs of 32 healthy controls and 40 LPSLs of 40 patients with unilateral noninflammatory SIP and a positive Fortin finger test. LPSLs in both groups were assessed for the presence of alterations in their structure, continuity and echogenicity and their thickness was measured in three predefined points.

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Patients with low back pain (LBP) frequently undergo various imaging studies in the pursuit of a more precise diagnosis. Ultrasound (US) has the advantage of being a widely available, multiplanar, fast and radiation-free diagnostic tool. Moreover, compared to most of the other imaging modalities, it is particularly efficient in the visualization and assessment of soft tissues.

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Article Synopsis
  • Erufosine, an injectable compound, shows strong anti-cancer effects on multiple myeloma (MM) cell lines, with its cytotoxicity linked to varying apoptotic and non-apoptotic mechanisms across different cell types.
  • The study demonstrated that erufosine's effectiveness in inducing cell death inversely correlates with the level of Bcl-X(L) protein and highlights its ability to inhibit cell migration and enhance the effects of other drugs.
  • Importantly, erufosine was not harmful to normal hematopoietic progenitor cells and even stimulated the growth of certain blood cell colonies, suggesting its potential as a safe and effective treatment for multiple myeloma.
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