Cytogenetic study of chronic myeloid leukemia.

A total of 122 patients with chronic myeloid leukemia (CML) were cytogenetically examined. At the first cytogenetic examination 68 of them were in chronic phase (CP) and 54 in blastic phase (BP) of the disease. The mean age of the whole group was 44.

Chromosomal characteristics and non-random distribution of sister chromatid exchanges in lymphoblastoid cell lines isolated from acute leukemias.

Serial cytogenetic characteristics of four lymphoblastoid cell lines derived from the peripheral blood of four patients with acute leukemia are presented, including G and C banding techniques and the analysis of sister chromatid exchanges by means of FPG technique. One of these lines turned into predominantly diploid although originally pseudodiploid, while the other three changed from diploid to heteroploid ones during prolonged cultivation, with the appearance of a marker chromosome in one of them. The mean number of sister chromatid exchanges per mitosis (9.