Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection.

Background: The outcome of surgically resected, apparently localized, clear cell renal carcinoma (ccRCC) is uncertain.

Objective: To evaluate if cell cycle progression (CCP) gene expression can predict future metastasis.

Methods: Pathologic T2a-T3b tumors at University of Iowa were reviewed.

Analytical validation of a proliferation-based molecular signature used as a prognostic marker in early stage lung adenocarcinoma.

Aims: The aim of these studies was to validate the analytical performance of a cell cycle progression (CCP) gene signature that provides prognostic information for early stage lung adenocarcinomas.

Materials & Methods: Formalin-fixed paraffin-embedded (FFPE) lung resections were evaluated by quantitative RT-PCR for the expression of 31 target and 15 housekeeper genes comprising the CCP score.

Results: The signature had a standard deviation (SD) of 0.