An Employer-Sponsored Musculoskeletal Care Coordination Service Can Improve Clinical Outcomes and Self-Reported Productivity.

Objective: To evaluate the effects of participation with a novel musculoskeletal care coordination service on clinical outcomes, self-reported productivity, and satisfaction.

Methods: Prospective analysis of participants using the service from January 1, 2019 to December 31, 2019.

Results: One hundred eighty nine participants were enrolled; 54 participants completed their recommended clinical pathway.

Evaluation of drill-induced heat transmission in an orbital model.

Purpose: To evaluate the influence of saline irrigation on temperature rise in orbit bones and the optic canal during high-speed drilling.

Methods: An experimental study measuring temperature rise in an orbit during high-speed drilling was conducted. The orbital rims, sphenoid bone, and optic canals of 6 unpreserved caprine orbits were drilled with a 3.

Effect of magnetic resonance exposure combined with gadopentetate dimeglumine on chromosomes in animal specimens.

Rationale And Objectives: We tested for the presence of a form of unstable chromosomal damage--anaphase bridges--that might result from the combined exposure to gadopentetate dimeglumine and magnetic resonance (MR) imaging in rats.

Methods: Fifty-four male Sprague-Dawley rats, along with appropriate controls, were exposed either to MR imaging alone, gadopentetate dimeglumine alone, or a combination of the two. After exposure, partial hepatectomies were performed to induce a vigorous mitotic response in the regenerating liver stump.

Effect on fetal mouse development of exposure to MR imaging and gadopentetate dimeglumine.

Pregnant mice were exposed to one of five regimens at 9.5 days of gestation: no treatment (group 1), intraperitoneal injection of normal saline (group 2), intraperitoneal injection of gadopentetate dimeglumine (group 3), intraperitoneal injection of gadopentetate dimeglumine and magnetic resonance (MR) exposure (group 4), and MR exposure alone (group 5). At 18 days of gestation, the mice were sacrificed and fetuses were removed and examined for the following end points: litter size, number alive or dead, fetal weight, extremity morphology, eye and ear development, and appearance of the head.

The effect of stress on proton relaxation times (T1 and T2) of rat liver.

T1 of the liver has been shown to lengthen after sham operation or partial hepatectomy, reaching a maximum about 24 hours after surgery. Surgical stress, which includes tissue injury and repair, has been suggested as the source of the change. We subjected rats to three types of stress that do not include tissue damage and repair to determine the role of stress alone in the length of T1 of the liver.

Effects of mitotic activity and water content on the proton relaxation times in partially hepatectomized and sham-operated rat livers.

Proton relaxation times, T1 and T2, water content, and mitotic activity in control, sham-operated and partially hepatectomized rat livers were measured before surgery, and at 28 hours, 48 hours and six days after surgery. T1, water content, and mitotic activity increased after partial hepatectomy, but T1 was also elevated after sham operations, whereas neither water content nor mitotic activity changed. T2 was unaffected by either procedure.

The carcinogenicity of radiation therapy.

Ionizing radiation as used for therapy for cancer is probably weakly carcinogenic at worst. The probability that cancers will be induced at a distance from the treatment volume is so small that it can only be inferred from experiences with large populations exposed to much higher radiation doses. The risk of cancer in and adjacent to the treatment volume also appears to be small, especially in adults.

Effect of pulsed low-power ultrasound on growing tissues. II. Malignant tissues.

Pulsed ultrasound at 2.25 MHz was delivered by a transducer having an average power output of 1.5 mW to a transplantable mouse lymphosarcoma for 5 min.

Influence of dose rate on carcinogenesis resulting from x-ray, 113In, and 198Au irradiation.

The potential hazards from internally administered radionuclides used in nuclear medicine are usually compared with one another and with diagnostic x-rays on the basis of the absorbed dose in rads, with no regard to the dose rate of the radiation. This study compared the carcinogenic potential of a dose of 250 rads delivered at different dose rates to rat livers by x-ray, 113mIn, and 198Au. The chemical carcinogen N-2-fluorenyldiacetamide was administered after irradiation to reduce the latent period and increase the number of radiogenic liver tumors.

Biological detection of reduction in dose at the surface of volume sources containing beta emitters.

Dosimetry theory related to volume sources containing uniformly distributed beta-emitting radionuclides predicts a rapid drop in dose at the outer surface to approximately one half of the maximum dose within the volume. The purpose of this study was to determine if this reduction in surface dose could be observed using a measurable biological endpoint. In this study rats were injected with radiocolloids of either 198Au, 113In-m or 99Tc-m, to produce liver irradiation from their decay, or their livers were treated with external X-irradiation.

A new approach to testing the effect of ultrasound on tissue growth and differentiation.

Pulsed ultrasound from a Picker Ultrasonoscopy Model 102, with a frequency of 500 Hz and an energy of 2.2 MHz was applied to the amputated left forelimbs of 24 adult newts. Exposure time was 5 min in half of the animals and 10 min in the remainder.