Rapid growth and slow involution of Reed nevus in a long-term dermoscopic follow-up.

We describe the rapid growth of a Reed nevus followed by its slow involution and present dermoscopic follow-up images. The child was monitored for 10 years (from age 3 to 13 years) by digital dermoscopy. The Reed nevus completely lost its typical dermoscopic arrangement (starburst pattern) with involution and distinct changes in dermoscopic pattern.

Clinical-Dermoscopic-Histopathological Correlations in Collision Skin Tumours.

Objectives: Collision tumours are rare situations characterised by the coincidence of two different skin neoplasms in the same lesion.

Methods: We have analyzed 41 collision skin tumours from one department in the clinical-dermoscopic-histopathologic correlations.

Results: We present 41 collisions tumours.

The use of 2940-nm ER:YAG laser for the treatment of lentigo maligna.

Objectives: Lentigo maligna is a common in situ malignancy in elderly patients, with a low risk of progression to an invasive tumor. Surgical treatment may be complicated or refused. Non-surgical treatment options (such as lasers) may therefore be needed.

A case of lupus-like syndrome in a patient receiving adalimumab and a brief review of the literature on drug-induced lupus erythematosus.

What Is Known And Objective: Drug-induced lupus erythematosus occurs with some drugs and resolves with their withdrawal. Anti-TNF therapies have been found to be associated with a lupus-like syndrome, which is clinically distinct from classical drug-induced as well as idiopathic lupus erythematosus.

Case Description: We describe a case of a patient with severe psoriasis, who developed muscle pain with paraesthesia accompanied by ANA titres elevation with adalimumab treatment.

Anogenital granulomatosis: report of two cases.

Anogenital granulomatosis (AGG) is a rare chronic inflammatory disorder of unknown aetiology. It presents clinically with swelling of the genital or anoperineal area, with histopathological findings of noncaseating giant cell granulomas. Some cases of AGG are associated with underlying systemic disease, mainly Crohn disease.

IgE-mediated sensitization to malassezia in atopic dermatitis: more common in male patients and in head and neck type.

Background: Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Malassezia, the predominant skin microbiota fungus, is considered to exacerbate AD, especially in a subset of patients with head and neck type AD (HNAD). In the present study, the relationship between AD and sensitization to Malassezia antigens was investigated.

[Difficult differential diagnosis of malignant melanoma--case reports].

Malignant melanoma is one of the most malignant tumours. If it is diagnosed in the early stage, the prognosis is quite good. Timely diagnosis is essential as well as early surgical removal of the tumour in a specialized centre.

Digital dermatoscopic follow-up of 1027 melanocytic lesions in 121 patients at risk of malignant melanoma.

Objective: The aim of the presented prospective study was to use a digital dermatoscopic system to follow-up patients with multiple melanocytic naevi, and to evaluate the frequency and character of dermatoscopic changes.

Methods: We monitored selected melanocytic lesions with the use of a 6-month follow-up interval between check-ups. We searched for changes in size, shape, symmetry, structure and colour.

TSC2/PKD1 contiguous gene syndrome: a report of 2 cases with emphasis on dermatopathologic findings.

The association of tuberous sclerosis complex (TSC) and autosomal dominant polycystic kidney disease (ADPKD), termed TSC2/PKD1 contiguous gene syndrome, is a result of molecular defect demonstrating by deletion disrupting TSC2 and PKD1. Dermatopathology of this syndrome has never been addressed. We report 2 sporadic cases form of TSC2/PKD1 contiguous gene syndrome, with emphasis on dermatopathologic findings.

Hyperplasia of hair follicles and other adnexal structures in cutaneous lymphoproliferative disorders: a study of 53 cases, including so-called pseudolymphomatous folliculitis and overt lymphomas.

We studied 53 cutaneous lymphoproliferative disorders, all of which manifested hair follicle hyperplasia. There were 42 cases conforming to the description of pseudolymphomatous folliculitis (PLF) and 11 cases of authentic lymphomas including mycosis fungoides, CD30+ anaplastic large cell lymphoma, diffuse large B-cell lymphoma, B-cell small cell lymphoma/leukemia, and peripheral T-cell lymphoma, not otherwise specified. All patients with PLF clinically presented with a solitary nodule preferentially involving the face.

Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells.

Hypericin, the major component of St. John's Wort, absorbs light in the UV and visible ranges whereupon it becomes phototoxic through the production of reactive oxygen species. Although photodynamic mechanisms (i.

Photodynamic therapy of nonmelanoma skin cancer with topical hypericum perforatum extract--a pilot study.

Hypericin, the photoactive compound of Hypericum perforatum, is probably the most powerful photosensitizer found in nature. This compound has shown high potency in the photodynamic treatment of tumor cells. However, there is only limited knowledge regarding the photodynamic effect of hypericin on nonmelanoma skin cancer cells.

Genital warts treated by photodynamic therapy.

The patient, a 30-year-old man with numerous genital condylomata acuminata (CA), has had unsuccessful treatment with liquid nitrogen, 20% podophyllin, and repeated 0.5% podophyllotoxin solution with 5% imiquimod (Figure 1). Before the appearance of CA, he experienced acute orchiepididimitis and a Candida infection.

Digital computer analysis of dermatoscopical images of 260 melanocytic skin lesions; perimeter/area ratio for the differentiation between malignant melanomas and melanocytic nevi.

Background: Digital computer analysis of dermatoscopical images has been reported to facilitate the differential diagnosis of pigmented skin lesions in recent years.

Objective: The aim of our study was to perform digital computer analysis of a set of different melanocytic lesions and compare the objective results.

Methods: The set of 260 melanocytic lesions (150 excised difficult cases (46 melanomas, 47 atypical nevi, 57 common nevi and 110 unexcised common nevi) was automatically analysed by the digital dermatoscopical system microDERM.

Coexisting subacute and systemic lupus erythematosus after terbinafine administration: successful treatment with mycophenolate mofetil.

A 39-year-old female patient with systemic lupus erythematosus was treated with terbinafine for onychomycosis. After only 7 days of treatment with 250 mg terbinafine, a widespread severe erythematous eruption developed. The results of clinical, histological and immunofluorescent examinations confirmed the diagnosis of coexisting subacute and systemic lupus erythematosus.

Dermatoscopic differences between atypical melanocytic naevi and thin malignant melanomas.

Dermatoscopy is used to aid in the differential diagnosis of pigmented skin lesions. The aim of this study was to identify dermatoscopic differences between atypical melanocytic naevi and thin malignant melanomas. A set of 180 difficult cases (60 thin melanomas, 120 clinically atypical benign melanocytic naevi) was analysed.

Cryosurgery in the treatment of earlobe keloids: report of seven cases.

Background: Keloids are benign cutaneous lesions that result from excessive collagen synthesis and deposition. Earlobe keloids in particular are seen as a complication of plastic surgery or piercing. Many different treatment modalities have been used, often with unsatisfactory results.

[The use of the 308 nm excimer laser for the treatment of psoriasis].

Background And Objective: Standard phototherapy for psoriasis (311 nm UVB or photochemotherapy) exposes the non-affected skin to potentially damaging irradiation. The use of 308 nm XeCl excimer laser allows the selective irradiation of psoriatic lesions. We evaluated its therapeutic effectiveness.