Signaling (in)tolerance: Social evaluation and metaethical relativism and objectivism.

Prior work has established that laypeople do not consistently treat moral questions as being objectively true or as merely true relative to different perspectives. Rather, these metaethical judgments vary dramatically across moral issues and in response to different social influences. We offer a potential explanation by examining how objectivists and relativists are evaluated in different contexts.

Praise Is for Actions That Are Neither Expected nor Required.

In six studies, we examined two foundational questions about moral praise. First, what makes an action praiseworthy? In Study 1, participants reported that actions that exceed duties (compared with dutiful actions) deserve greater praise and are perceived as less likely to happen. Second, what do observers infer from praise? Praise may communicate information about local norms.

Are there conserved biosynthetic genes in lichens? Genome-wide assessment of terpene biosynthetic genes suggests ubiquitous distribution of the squalene synthase cluster.

Lichen-forming fungi (LFF) are prolific producers of functionally and structurally diverse secondary metabolites, most of which are taxonomically exclusive and play lineage-specific roles. To date, widely distributed, evolutionarily conserved biosynthetic pathways in LFF are not known. However, this idea stems from polyketide derivatives, since most biochemical research on lichens has concentrated on polyketide synthases (PKSs).

Neural patient-specific 3D-2D registration in laparoscopic liver resection.

Purpose: Augmented reality guidance in laparoscopic liver resection requires the registration of a preoperative 3D model to the intraoperative 2D image. However, 3D-2D liver registration poses challenges owing to the liver's flexibility, particularly in the limited visibility conditions of laparoscopy. Although promising, the current registration methods are computationally expensive and often necessitate manual initialisation.

Cloprostenol effect with and without male stimulation on oestrus synchronization in Peru guinea pigs.

Cloprostenol, a synthetic derivative of prostaglandin F, effectively triggers functional and morphological regression of the corpus luteum (luteolysis). In rural Peru, the guinea pig (Cavia porcellus) holds significance within the local economy and serves as a valuable protein source. Enhancing reproductive efficiency is crucial to achieve uniformity in weight, age, and litter size across commercial systems.

Detection of Anomalies in Daily Activities Using Data from Smart Meters.

The massive deployment of smart meters in most Western countries in recent decades has allowed the creation and development of a significant variety of applications, mainly related to efficient energy management. The information provided about energy consumption has also been dedicated to the areas of social work and health. In this context, smart meters are considered single-point non-intrusive sensors that might be used to monitor the behaviour and activity patterns of people living in a household.

Microencapsulated essential oils influence the growth and foregut histomorphometry of Nile tilapia () fingerlings.

Essential oils supplementation has potential growth-promoting, antibacterial, and immunostimulatory effects for various fish species. Dietary supplementation with essential oils improves Nile tilapia's growth and intestinal morphology. The aim of the study was to assess the effect of supplementation with microencapsulated essential oils (MEOs) containing cinnamaldehyde (53.

The Prognostic Significance of Tumor-Infiltrating Lymphocytes, PD-L1, BRCA Mutation Status and Tumor Mutational Burden in Early-Stage High-Grade Serous Ovarian Carcinoma-A Study by the Spanish Group for Ovarian Cancer Research (GEICO).

Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to determine the prognostic significance of CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs), tumoral cell PD-L1 expression, mutational status and tumor mutation burden (TMB) in early-stage HGSOC. A retrospective study was performed on stage I and II HGSOC from the Molecular Reclassification of Early Stages of Ovarian Cancer (RECLAMO) cohort from the Spanish Group of Ovarian Cancer Research (GEICO).

Exploring the Effects of Tasks with Different Decision-Making Levels on Ball Control, Passing Performance, and External Load in Youth Football.

This study aimed to understand how the design of decision-making tasks affects youth football players' ball control, passing performance, and external load. A total of 16 male youth football players (age: 12.94 ± 0.

On the Highway to Hell: Slippery Slope Perceptions in Judgments of Moral Character.

Across four studies, we test the hypothesis that people exhibit "slippery slope" thinking in their judgments of moral character-that is, do observers judge that a person who behaves immorally will become increasingly immoral over time? In Study 1, we find that a person who commits an immoral act is judged as more likely to behave immorally and as having a worse character in the future than in the past. In Study 2, we find that it is the of an immoral act specifically-rather than merely attempting an immoral act-that drives this slippery slope effect. In Study 3, we demonstrate that observers judge the moral agent as more likely to commit acts of greater severity further in time after the initial immoral act.

Progression to lung fibrosis in severe COVID-19 patients: A morphological and transcriptomic study in postmortem samples.

The development of lung fibrosis is a major concern in patients recovered from severe COVID-19 pneumonia. This study aimed to document the evolution of diffuse alveolar damage (DAD) to the fibrosing pattern and define the transcriptional programs involved. Morphological, immunohistochemical and transcriptional analysis were performed in lung samples obtained from autopsy of 33 severe COVID-19 patients (median illness duration: 36 days).

The Clonal Relationship Between the Ductal and Lobular Components of Mixed Ductal-Lobular Carcinomas Suggested a Ductal Origin in Most Tumors.

The relationship between the ductal and lobular components of invasive ductolobular carcinomas (IDLC) has not been fully elucidated. In this study, the molecular alterations of both components were analyzed in a series of 20 IDLC that were selected, not only by morphologic criteria, but also by the loss of E-cadherin expression in the lobular component. We found that 80% of tumors shared alterations of driver genes in both components, being PIK3CA the most common alteration.

Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestations.

Severe cases of Coronavirus Disease 2019 (COVID-19) can present with multiple neurological symptoms. The available neuropathological studies have described different lesions; the most frequent was the presence of neuroinflammation and vascular-related lesions. The objective of this study was to report the neuropathological studies performed in a medical institution, with abundant long intensive care unit stays, and their associated clinical manifestations.

A peptide blocking the ADORA1-neurabin interaction is anticonvulsant and inhibits epilepsy in an Alzheimer's model.

Epileptic seizures are common sequelae of stroke, acute brain injury, and chronic neurodegenerative diseases, including Alzheimer's disease (AD), and cannot be effectively controlled in approximately 40% of patients, necessitating the development of novel therapeutic agents. Activation of the A1 receptor (A1R) by endogenous adenosine is an intrinsic mechanism to self-terminate seizures and protect neurons from excitotoxicity. However, targeting A1R for neurological disorders has been hindered by side effects associated with its broad expression outside the nervous system.

RNA SARS-CoV-2 Persistence in the Lung of Severe COVID-19 Patients: A Case Series of Autopsies.

The exact role of viral replication in patients with severe COVID-19 has not been extensively studied, and it has only been possible to demonstrate the presence of replicative virus for more than 3 months in a few cases using different techniques. Our objective was to study the presence of RNA SARS-CoV-2 in autopsy samples of patients who died from COVID-19 long after the onset of symptoms. Secondary superimposed pulmonary infections present in these patients were also studied.

Direct Cortical Stimulation to Probe the Ictogenicity of the Epileptogenic Nodes in Temporal Lobe Epilepsy.

Accurate mapping of the seizure onset zone (SOZ) is critical to the success of epilepsy surgery outcomes. Epileptogenicity index (EI) is a statistical method that delineates hyperexcitable brain regions involved in the generation and early propagation of seizures. However, EI can overestimate the SOZ for particular electrographic seizure onset patterns.

Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis.

Cutaneous metastases (CMs) account for 2% of all skin malignancies, and nearly 70% of CMs in women originate from breast cancer (BC). CMs are usually associated with poor prognosis, are difficult to treat, and can pose diagnostic problems, such as in histopathological diagnosis when occurring long after development of the primary tumor. In addition, the molecular differences between the primary tumors and their CMs, and between CMs and metastases in other organs, are not well defined.

Using Perspective-n-Point Algorithms for a Local Positioning System Based on LEDs and a QADA Receiver.

The research interest on location-based services has increased during the last years ever since 3D centimetre accuracy inside intelligent environments could be confronted with. This work proposes an indoor local positioning system based on LED lighting, transmitted from a set of beacons to a receiver. The receiver is based on a quadrant photodiode angular diversity aperture (QADA) plus an aperture placed over it.

[Personal and familial features associated with organ donation in Chilean adults].

Background: The rates of organ donation are alarmingly low in Chile.

Aim: To determine the relationship between social and family characteristics that influence the decision to donate organs and tissues among adults.

Material And Methods: The questionnaire developed in Spain by the international collaborative project on organ transplantation and donation, developed and validated in Chile was applied to 383 adults aged 40 ± 17 years (mostly women), living in Coquimbo, Chile.

How the Number of Players and Floaters' Positioning Changes the Offensive Performance during Futsal Small-Sided and Conditioned Games.

This study aims to analyse the effects of floater positioning within futsal Gk + 3vs3 + Gk and Gk + 2vs2 + Gk small-sided and conditioned games (SSCG) on youth offensive performance on an action per minute per player basis. Three experimental conditions were carried out through the manipulation of floater positioning: floaters off (FO), final line floaters (FLF) and lateral floaters (LF). Thirty male futsal players (U19 age category) participated in the study and played once within each situation in a random order on different days.

Epithelial Mesenchymal Transition and Immune Response in Metaplastic Breast Carcinoma.

Metaplastic breast carcinoma (MBC) is a heterogeneous group of infrequent triple negative (TN) invasive carcinomas with poor prognosis. MBCs have a different clinical behavior from other types of triple negative breast cancer (TNBC), being more resistant to standard chemotherapy. MBCs are an example of tumors with activation of epithelial-mesenchymal transition (EMT).

Robust Isometric Non-Rigid Structure-From-Motion.

Non-Rigid Structure-from-Motion (NRSfM) reconstructs a deformable 3D object from keypoint correspondences established between monocular 2D images. Current NRSfM methods lack statistical robustness, which is the ability to cope with correspondence errors. This prevents one to use automatically established correspondences, which are prone to errors, thereby strongly limiting the scope of NRSfM.

How Informational Constraints for Decision-Making on Passing, Dribbling and Shooting Change With the Manipulation of Small-Sided Games Changes in Futsal.

In this study, we explored how manipulating floaters' positions in small-sided futsal games (SSGs) promote changes in the informational constraints that support decision-making (DM) for passing, dribbling and shooting tactics. We made changes in four experimental 3 vs 3 small-sided game conditions with 30 male futsal players (U19 age category): (a) Floaters Off (FO), (b) Final Line Floaters (FLF), (c) Lateral Floaters own field sideline (LFofsl) and (d) Lateral Floaters full field sideline (LFffsl). We assessed players' activity with WIMU PRO™ software during the SSGs, using the Game Performance Evaluation Tool (GPET) to analyze a total of 1,635 decisions.