Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial.

Background: Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy in chemoprevention. Previous chemoprevention randomised controlled trials (RCTs) did not individually show benefit of HCQ against COVID-19 and, although meta-analysis did suggest clinical benefit, guidelines recommend against its use.

Methods And Findings: Healthy adult participants from the healthcare setting, and later from the community, were enrolled in 26 centres in 11 countries to a double-blind, placebo-controlled, randomised trial of COVID-19 chemoprevention.

Good participatory practice for coronavirus disease 2019 (COVID-19) research: the case of a COVID-19 prevention study.

The COPCOV study (chloroquine/ hydroxychloroquine prevention of coronavirus disease), which started recruitment in April 2020, is a multi-country double-blind, randomised, placebo-controlled trial which is being conducted in healthcare facilities involved in COVID-19 case management. Participants are staff employed in facilities managing people with proven or suspected COVID-19. As part of the study, we conducted a series of engagement sessions.

Modeling the future impacts of climate change on water availability in the Karnali River Basin of Nepal Himalaya.

It's unequivocal that the global climate is changing, including the rise in atmospheric temperature and variability in amount and pattern of precipitation, and the rate of temperature change in the Himalayan region is higher than the global average. Since precipitation and temperature are the major driving factors of water resources in the Himalayas both upstream and downstream regions, it is important to understand theimpacts of climate change in water resource availability in the future. In this study, we analyzed the historical hydro-climate data and developed a suitable ensemble of the Coordinated Regional Downscaling Experiment (CORDEX) climate models for the Karnali River Basin (KRB) in western Nepal and assessed the future water availability in different climate scenarios using a semi-distributed catchment scale hydrological model the Soil and Water Assessment Tool (SWAT).

Evaluating climatic and non-climatic stresses for declining surface water quality in Bagmati River of Nepal.

Both climatic and non-climatic factors affect surface water quality. Similar to its effect across various sectors and areas, climate change has potential to affect surface water quality directly and indirectly. On the one hand, the rise in temperature enhances the microbial activity and decomposition of organic matter in the river system and changes in rainfall alter discharge and water flow in the river ultimately affecting pollution dilution level.