Highly potent oligostilbene sbLOX-1 inhibitor from Gnetum macrostachyum.

Isolated oligostilbenes from G. macrostachyum exhibited sbLOX-1 inhibitory activity with IC50 values ranging from 0.14-11.

Stilbenoids from Gnetum macrostachyum attenuate human platelet aggregation and adhesion.

Platelets play a critical role in pathogenesis of cardiovascular disorders and strokes. The inhibition of platelet function is beneficial for the treatment and prevention of these diseases. The phytochemical investigation of stilbenoids from Gnetum macrostachyum Hook.

Macrostachyols A-D, new oligostilbenoids from the roots of Gnetum macrostachyum.

Four new oligostilbenes, macrostachyols A-D (1-4) along with six known stilbenoids (5-10), were isolated from the roots of Gnetum macrostachyum. These compounds were also evaluated for their cytotoxicity towards HeLa and KB cell lines. Only compound 4 showed the significant cytotoxicity to HeLa cells with IC(50) value of 4.