Publications by authors named "Piyapat Trisonthi"
Article Synopsis
- Cyanobacteria, particularly the species Arthrospira, are rich in nutrients and natural pigments with numerous health benefits, prompting a study to optimize their extraction for maximum phenolic content and antioxidant activity.
- Through specific methods, the research determined effective extraction conditions that enhanced the yield of beneficial compounds, with A. maxima outperforming A. platensis in terms of bioactive content and enzyme inhibition properties.
- The study reveals that both species can inhibit key enzymes related to diseases like diabetes and Alzheimer's, with a notable synergy found between Arthrospira extracts and the Alzheimer's drug donepezil in inhibiting a critical enzyme linked to the disease.
Article Synopsis
- The study focused on encapsulating bioactive compounds from a specific extract using freeze-drying to improve their solubility and stability for food and pharmaceutical applications.
- The effectiveness of different wall materials (maltodextrin, gum arabic, and their combination) was tested, revealing that the combination provided the best protection for the bioactive compounds and enhanced their biological activity.
- Results indicated that the encapsulated extracts promoted cell viability and osteogenesis in pre-osteoblast cells, suggesting potential for osteoporosis prevention in food or pharmaceutical products.
Article Synopsis
- * This research focused on the phenolic profiles and health benefits of 29 herbal ingredients in two Thai remedies, finding some with potential to combat chronic diseases.
- * Notable extracts showed promise: Biancaea sappan scored highest for antioxidant potential, Bouea macrophylla inhibited diabetes-related enzymes, Dischidia major targeted hypertension, and Dracaena cochinchinensis could aid in Alzheimer's treatment.
Article Synopsis
- - The
- sacred lotus
- is widely used in Asia for food and traditional medicine due to its high levels of beneficial compounds like phenolics and alkaloids.
- - A study examined the
- seasonal variations
- in total phenolic contents and their related health benefits across different parts of the lotus plant, finding that the stamen consistently showed
- higher antioxidant activities and enzyme inhibitions
- relevant to chronic diseases.
- - The
- best time
- to harvest lotus stamen for its health benefits is at the
- beginning of the rainy season
- , as it has significantly higher phenolic content and biochemical activities compared to other seasons, providing valuable information for lotus cultivation and potential future product development.
Article Synopsis
- - Alzheimer's disease is a neurological condition that has limited treatment options, leading researchers to explore the potential of natural products, such as tropical fruits, for therapeutic effects.
- - Ten tropical fruits were tested for their ability to inhibit cholinesterases and β-secretase, key enzymes in the progression of Alzheimer's, with 'Kaew', 'Namdokmai', and 'Kimju' showing the most promising results.
- - 'Namdokmai' particularly demonstrated effectiveness by reducing neurotoxicity related to Aβ peptides and inhibiting BACE-1, suggesting its potential as a therapeutic option for Alzheimer's disease.
Article Synopsis
- Thailand grows a wide range of tropical fruits, but research on their health benefits, particularly their phytonutrients and effects on diseases like obesity and diabetes, is limited.
- A study analyzed the phytochemical profiles and enzyme-inhibiting properties of eight tropical fruit extracts, with 'Namdokmai' showing the highest antioxidant levels and significant inhibition of enzymes related to obesity and diabetes.
- All extracts, especially 'Namdokmai' and 'Khaekdum', were effective in reducing DNA mutations caused by food mutagens, suggesting that consuming these fruits may help counteract the negative effects of overcooked meats.
A new diterpene, identified as (+)-6-(4-hydroxy-4-methyl-2-pentenoyl)-4,6-dimethyl-5-(3-methyl-2-butenyl)-1,3-cyclohexadienecarbaldehyde (1, cubelin), was isolated from a methanol extract of Litsea cubeba fruits by normal phase column chromatography and purified by preparative HPLC. The structure elucidation was conducted by spectroscopic methods (UV, IR, ESI-TOF-MS, 1-D and 2-D NMR). Cubelin exhibited activity against HeLa cell viability and proliferation.
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