Publications by authors named "Piver Pascal"
Introduction: Ovarian tissue cryopreservation (OTC) is recommended by scientific societies for women undergoing highly gonadotoxic cancer treatments. Following transplantation, the restoration of ovarian function is typically characterised by the resumption of spontaneous menstruation. Yet, a few studies have looked at the longitudinal hormonal variations following transplantation.
View Article and Find Full Text PDFUterine factor infertility (UFI) is defined as a condition resulting from either a complete lack of a uterus or a non-functioning uterus due to many causes. The exact prevalence of UFI is currently unknown, while treatments to achieve pregnancy are very limited. To evaluate the prevalence of this condition within its different causes, we carried out a worldwide systematic review on UFI.
View Article and Find Full Text PDFIntroduction: Most gynecological residents or junior surgeons do not practice nor experience robotic surgery due to lack of access during residency or poor knowledge about this growing surgical technology. This study evaluated the feasibility and safety of a 3-half-day experiencing and training session for robot-assisted gynecological surgery designed for residents and fellows.
Materiel And Methods: This is a prospective, single-center observational study about a training course aimed at residents or fellows at the university teaching hospital of Limoges (France).
: Uterus transplantation (UTx) is a promising treatment for uterine infertility that has resulted in several births since 2014. Ischemia is a key step in organ transplantation because it may lead to changes jeopardizing graft viability. : We performed a systematic review of animal and human studies relating to uterine ischemia.
View Article and Find Full Text PDFUterus transplantation in transgenders: Will it happen one day?
J Gynecol Obstet Hum Reprod
January 2019
Article Synopsis
- Absolute uterine factor infertility affects thousands of young women in France, leading to the development of uterus transplantation as a solution since the first successful birth in 2014.
- The French College of Gynaecologists and Obstetricians established a committee in 2015 to promote this technology, creating criteria for Uterus Transplantation Centres.
- The committee's guidelines detail the responsibilities of these centres in areas such as patient care, training, research, and geographical coverage to effectively manage patients needing uterus transplants.
Aim: To describe class I and II human leucocyte antigen (HLA) expression using different uterine tissues in the perspective of uterus transplantation.
Methods: Human uterine tissues were obtained from 12 women who had undergone hysterectomy for the treatment of benign disease. HLA class I and HLA-antigen D related (DR) expression were assessed via immunochemistry.
Background: The aim of this systematic review was to evaluate and compare the pros and cons of using living donors or brain-dead donors in uterus transplantation programs, 2 years after the first worldwide live birth after uterus transplantation.
Methods: The Medline database and the Central Cochrane Library were used to locate uterine transplantation studies carried out in human or nonhuman primates. All types of articles (case reports, original studies, meta-analyses, reviews) in English or French were considered for inclusion.
Objective: To describe the feasibility of human uterus retrieval after donation after brain death.
Design: Single-center, prospective study.
Setting: University hospital.
Aim: Our goal was to demonstrate the feasibility of pelvic magnetic resonance imaging (MRI) in the ewe.
Material And Methods: Two ewes underwent a pelvic 3 Tesla MRI scan, under light anesthesia, with T2-weighted fast spin-echo images and T1-weighted spoiled gradient-echo images. Multiplan T1 weighted images were also obtained after the intravenous injection of a contrast product.
INTRODUCTION. Premature ovarian failure (POF) can occur naturally at an early age or be due to iatrogenic agents. Indeed, ovaries are very sensitive to cytotoxic treatment, especially to radiation and alkylating agents.
View Article and Find Full Text PDFAim: To prospectively study the influence of the uterine junctional zone thickness measured on pelvic magnetic resonance imaging (MRI), on implantation rates during in vitro fertilization (IVF).
Methods: A prospective clinical-imaging study was conducted and included 152 female patients. Patients had a positive diagnosis of infertility and an indication for IVF.
Agressive chemotherapy can lead to premature ovarian failure and loss of fertility in women and children. Embryo cryopreservation is an established clinical procedure of fertility preservation but with several limitations. Others options are available.
View Article and Find Full Text PDFArticle Synopsis
- The first case reported involves a woman with sickle cell anemia who successfully restored ovarian activity and achieved a live birth after undergoing cryopreserved ovarian tissue autograft following bone marrow transplantation.
- The procedure included harvesting and cryopreserving ovarian tissue before chemotherapy and performing an autotransplantation of thawed ovarian cortex after the patient became menopausal due to treatment.
- This successful outcome highlights the potential of ovarian tissue cryopreservation and autotransplantation as a fertility preservation method for young patients facing high risks of premature ovarian failure due to non-cancerous medical treatments.