Understanding older adults' needs for and perceptions of shared autonomous vehicle interior features: A focus group and user enactment study.

Shared autonomous vehicles (SAVs) can help older adults maintain mobility and independence throughout the later stages of life. However, research is critically needed to assess the design of SAV interior features and quantify potential mobility challenges for older populations. This paper presents a study that adopted a mixed-methods approach to evaluate the needs and perceptions of adults aged 65 years and older regarding interior features of SAVs during user enactment, and offers data-driven insights on task performance to inform design decisions.

Perceived Negative Effects of Tic Management Strategies in Adults With Tic Disorders.

Behavior therapy is a well-established and empirically supported treatment for tic disorders (TDs). However, concerns have been expressed about the negative effects of behavioral interventions, such as tic worsening, tic substitution, and excessive effort. This study explored perceived negative effects of tic management strategies in adults with TDs and predictors of these experiences.

Implementing an Adult Extracorporeal Membrane Oxygenation Program During the COVID-19 Pandemic.

Background: In response to the needs of patients infected with COVID-19, an interdisciplinary team was assembled to implement an adult extracorporeal membrane oxygenation (ECMO) program in the surgical ICU of a West Texas tertiary care hospital. Use of Extracorporeal Life Support Organization (ELSO) guidelines was essential to the development of this effort.

Aim: The aim of this project was to develop, implement, and evaluate an adult ECMO program.

An Eye-Fixation Related Electroencephalography Technique for Predicting Situation Awareness: Implications for Driver State Monitoring Systems.

Objective: This study developed a fixation-related electroencephalography band power (FRBP) approach for situation awareness (SA) assessment in automated driving.

Background: Maintaining good SA in Level 3 automated vehicles is crucial to drivers' takeover performance when the automated system fails. A multimodal fusion approach that enables the analysis of the visual behavioral and cognitive processes of SA can facilitate real-time assessment of SA in future driver state monitoring systems.

Behavioral Interventions for Children and Adults with Tic Disorder.

Over the past decade, behavioral interventions have become increasingly recognized and recommended as effective first-line therapies for treating individuals with tic disorders. In this article, we describe a basic theoretical and conceptual framework through which the reader can understand the application of these interventions for treating tics. The three primary behavioral interventions for tics with the strongest empirical support (habit reversal, Comprehensive Behavioral Intervention for Tics, and exposure and response prevention) are described.

Informing Use of the Patient Health Questionnaire-2 to Detect Moderate or Greater Depression Symptoms in Adolescents and Young Adults in Outpatient Primary Care.

Objective: We compared the Patient Health Questionnaire (PHQ)-2 to the PHQ-9 and examined the implications of using various cutoff scores on the PHQ-2 to detect moderate or greater depressive symptoms on the PHQ-9. We hypothesized that a cutoff score of ≥2 would be optimal for detecting scores of ≥10 on the PHQ-9.

Methods: Demographic and depression screening data from 3,256 routine preventive visits for patients aged 12-25 years at the adolescent and young adult clinic at Children's Hospital Colorado between March 2017 and July 2019 were collected retrospectively.

Cueing natural event boundaries improves memory in people with post-traumatic stress disorder.

People with post-traumatic stress disorder (PTSD) often report difficulty remembering information in their everyday lives. Recent findings suggest that such difficulties may be due to PTSD-related deficits in parsing ongoing activity into discrete events, a process called event segmentation. Here, we investigated the causal relationship between event segmentation and memory by cueing event boundaries and evaluating its effect on subsequent memory in people with PTSD.

The self-management and transition manual "ALL YOU NEED IS LOVE" for adolescents with chronic kidney disease.

Purpose: To examine the effects of "ALL YOU NEED IS LOVE", a novel six-week, self-directed patient education manual designed to improve chronic kidney disease knowledge/self-management, health care transition readiness, self-advocacy, and mindfulness skills among adolescents with chronic kidney disease.

Design And Methods: We enrolled 49 adolescents aged 11-17 years (mean age 14.7 ± 1.

Age is more than just a number: The relationship among age, non-chronological age factors, self-perceived driving abilities, and autonomous vehicle acceptance.

Globally, adults aged 65 and older are a rapidly-growing population. Aging is associated with declines in perceptual, cognitive, and physical abilities, which often creates challenges in completing daily activities, such as driving. Autonomous vehicles (AVs) promise to provide older adults one way to maintain their mobility and independence.

PTSD is associated with impaired event processing and memory for everyday events.

Current theories of posttraumatic stress disorder (PTSD) propose that memory abnormalities are central to the development and persistence of symptoms. While the most notable memory disturbances in PTSD involve memory for the trauma itself, individuals often have trouble remembering aspects of everyday life. Further, people with PTSD may have difficulty segmenting ongoing activity into discrete units, which is important for our perception and later memory of the activity.

Validity of the 6-Minute Walk Test and YMCA Submaximal Cycle Test During Midpregnancy.

Tinius, RA, Blankenship, M, Maples, JM, Pitts, BC, Furgal, K, Norris, ES, Hoover, DL, Olenick, A, Lambert, J, and Cade, WT. Validity of the 6-minute walk test and Young Men's Christian Association (YMCA) submaximal cycle test during midpregnancy. J Strength Cond Res 35(11): 3236-3242, 2021-Submaximal exercise testing can be a feasible alternative to maximal testing within special populations to safely predict fitness levels; however, submaximal exercise testing has not been well-validated for use during pregnancy.

Takeover requests for automated driving: The effects of signal direction, lead time, and modality on takeover performance.

Vehicle-to-driver takeover will still be needed in semi-autonomous vehicles. Due to the complexity of the takeover process, it is important to develop interfaces to support good takeover performance. Multimodal displays have been proposed as a candidate for the design of takeover requests (TORs), but many questions remain unanswered regarding the effectiveness of this approach.

The effects of age and physical exercise on multimodal signal responses: Implications for semi-autonomous vehicle takeover requests.

The present study examined whether the non-chronological age factor, engagement in physical exercise, affected responses to multimodal (combinations of visual, auditory, and/or tactile) signals differently between younger and older adults in complex environments. Forty-eight younger and older adults were divided into exercise and non-exercise groups, and rode in a simulated Level 3 autonomous vehicle under four different task conditions (baseline, video watching, headway estimation, and video-headway combination), while being asked to respond to various multimodal warning signals. Overall, bi- and trimodal warnings had faster response times for both age groups across driving conditions, but was more pronounced for older adults.

Semantic knowledge attenuates age-related differences in event segmentation and episodic memory.

While semantic and episodic memory may be distinct memory systems, their interdependence is substantial. For instance, decades of work have shown that semantic knowledge facilitates episodic memory. Here, we aim to clarify this interactive relationship by determining whether semantic knowledge facilitates the acquisition of new episodic memories, in part, by influencing an encoding mechanism, event segmentation.

Using eye-tracking to investigate the effects of pre-takeover visual engagement on situation awareness during automated driving.

Automated driving systems are becoming increasingly prevalent throughout society. In conditionally automated vehicles, drivers may engage in non-driving-related tasks (NDRTs), which can negatively affect their situation awareness (SA) and preparedness to resume control of the vehicle, when necessary. Previous work has investigated engagement in NDRTs, but questions remain unanswered regarding its effect on drivers' SA during a takeover event.

Physiological Measurements of Situation Awareness: A Systematic Review.

Objective: The goal of this systematic literature review is to investigate the relationship between indirect physiological measurements and direct measures of situation awareness (SA).

Background: Across different environments and tasks, assessments of SA are often performed using techniques designed specifically to directly measure SA, such as SAGAT, SPAM, and/or SART. However, research suggests that indirect physiological sensing methods may also be capable of predicting SA.

Lessons Learned: Identifying Items Felt To Be Critical to Leading a Pediatric Palliative Care Program in the Current Era of Program Development.

The experience of starting and growing a pediatric palliative care program (PPCP) has changed over the last 10 years as rapid increases of patient volume have amplified challenges related to staffing, funding, standards of practice, team resilience, moral injury, and burnout. These challenges have stretched new directors' leadership skills, yet, guidance in the literature on identifying and managing these challenges is limited. A convenience sample of 15 PPCP directors who assumed their duties within the last 10 years were first asked the following open-ended question: What do you wish you had known before starting or taking over leadership of a PPCP? Responses were grouped into themes based on similarity of content.

Dynamic interplay between PTSD symptoms and posttraumatic growth in older military veterans.

Background: Posttraumatic growth (PTG) refers to positive psychological changes that may occur after experiencing a traumatic event. While cross-sectional studies have suggested that posttraumatic stress disorder (PTSD) is associated with greater PTG, few longitudinal studies have evaluated interrelationships between PTSD and PTG. Further, little is known about which specific symptom clusters of PTSD and coping mechanisms may drive PTG over time.

Permeability enhancers sensitize β-lactamase-expressing Enterobacteriaceae and Pseudomonas aeruginosa to β-lactamase inhibitors, thereby restoring their β-lactam susceptibility.

Objectives: β-lactamases are the major resistance determinant for β-lactam antibiotics in Gram-negative bacteria. Although there are β-lactamase inhibitors (BLIs) available, β-lactam-BLI combinations are increasingly being neutralised by diverse mechanisms of bacterial resistance. This study hypothesised that permeability-increasing antimicrobial peptides (AMPs) could lower the amount of BLIs necessary to sensitise bacteria to antibiotics that are β-lactamase substrates.

Depression and Cognitive Dysfunction in Older U.S. Military Veterans: Moderating Effects of BDNF Val66Met Polymorphism and Physical Exercise.

Objective: Depression is associated with increased risk for cognitive dysfunction, yet little is known about genetic and behavioral factors that may moderate this association. Using data from a nationally representative sample of older U.S.

Nisin penetration and efficacy against Staphylococcus aureus biofilms under continuous-flow conditions.

Biofilms may enhance the tolerance of bacterial pathogens to disinfectants, biocides and other stressors by restricting the penetration of antimicrobials into the matrix-enclosed cell aggregates, which contributes to the recalcitrance of biofilm-associated infections. In this work, we performed real-time monitoring of the penetration of nisin into the interior of Staphylococcus aureus biofilms under continuous flow and compared the efficacy of this lantibiotic against planktonic and sessile cells of S. aureus.

A permeability-increasing drug synergizes with bacterial efflux pump inhibitors and restores susceptibility to antibiotics in multi-drug resistant Pseudomonas aeruginosa strains.

Resistance to antibiotics poses a major global threat according to the World Health Organization. Restoring the activity of existing drugs is an attractive alternative to address this challenge. One of the most efficient mechanisms of bacterial resistance involves the expression of efflux pump systems capable of expelling antibiotics from the cell.

BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise.

The Met allele of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced levels of BDNF release, heightened hypothalamic-pituitary-adrenal axis reactivity, and impaired fear extinction. As a result, Met allele carriers may be at risk for greater severity of posttraumatic stress disorder (PTSD) symptoms. In this study, we examined the relationship between the BDNF Val66Met polymorphism and PTSD symptoms in two nationally representative samples of European American U.

Investigating the Kinetics of Montmorillonite Clay-Catalyzed Conversion of Anthracene to 9,10-Anthraquinone in the Context of Prebiotic Chemistry.

Carbonaceous meteorites contributed polycyclic aromatic hydrocarbons (PAHs) to the organic inventory of the primordial Earth where they may have reacted on catalytic clay mineral surfaces to produce quinones capable of functioning as redox species in emergent biomolecular systems. To address the feasibility of this hypothesis, we assessed the kinetics of anthracene (1) conversion to 9,10-anthraquinone (2) in the presence of montmorillonite clay (MONT) over the temperature range 25 to 250 °C. Apparent rates of conversion were concentration independent and displayed a sigmoidal relationship with temperature, and conversion efficiencies ranged from 0.