Publications by authors named "Pitithat Puranachot"
Article Synopsis
- Cell-free DNA (cfDNA) analysis can noninvasively predict outcomes in osteosarcoma by examining the size distribution of cfDNA fragments in patients compared to healthy donors.
- A study involving 50 osteosarcoma patients found that their cfDNA fragments were significantly shorter than those of healthy individuals, offering a high rate of diagnostic accuracy (100% specificity and sensitivity).
- The research concluded that shorter cfDNA fragments (≤150 bp) serve as important prognostic indicators and enhance the detection of mutations, potentially helping to identify patients with worse outcomes.
Liquid biopsies hold great promise for the management of cancer. Reliable liquid biopsy data depend on stable and reproducible pre-analytical protocols that comply with quality measures, irrespective of the sampling and processing site. We established a workflow for plasma preservation, followed by processing, cell-free nucleic acid isolation, quantification, and enrichment of potentially tumor-derived cell-free DNA and RNA.
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