Composite membrane of bacterially-derived cellulose and molecularly imprinted polymer for use as a transdermal enantioselective controlled-release system of racemic propranolol.

A composite membrane for transdermal delivery of S-propranolol enantiomer was developed based on the controlled pore functionalization of bacterial cellulose membranes using a molecularly imprinted polymer (MIP) layer synthesis. The reactive pore-filling of an asymmetric porous cellulose membrane with a MIP thin-layer was effected using a silanized coupler as an additional anchor for the MIP. MIP thin-layers with specific binding sites for S-propranolol were synthesized by copolymerization of methacrylic acid with a cross-linker, ethylene glycol dimethacrylate in the presence of S-propranolol as the template molecule and the latter was subsequently extracted.

Analgesic and antipyretic activities of the aqueous extract of Urtica macrorrhiza in experimental animals.

Oral administration of the aqueous extract of the stem of Urtica macrorrhiza (100-400 mg/kg) dose dependently reduced the number of writhings and stretchings induced by acetic acid and decreased licking activity of the late phase in formalin test at doses of 200 and 400 mg/kg. At doses of 200 and 400 mg/kg, p.o.