[Lipid peroxidation and the role of quaternary ammonium compounds in normalizing this process].

Regulation of lipid peroxidation is realized not only by antioxidant enzymes but by natural antioxidants as well. We have lately succeeded, together with the students, in identifying antioxidant properties of quaternary ammonium compounds, which fact makes it possible for the above properties to gain extensive applicability in a setting where there is this variety of disbolism. One of such drug preparations is ethonium.

[The antioxidant activity of bis-quaternary ammonium compounds of the methylene series].

Experiments on albino rats were made to reveal antioxidant activity of bisquaternary ammonium compounds of the methylene series (ethonium, thionium and dodeconium). It is determined by the enhancement of superoxide anion radicals neutralization and splitting of lipoperoxides.

[The antistaphylococcal activity of thionium in in vitro experiments].

The paper deals with the experimental study of antistaphylococcal properties of thionium--a derivative of bis-quarternary ammonium compounds. High bactericide activity of the preparation is revealed as a result; it is preserved under high contents of protein substances in the media. The sensitivity of staphylococcal strains to thionium is not affected by the initial sensitivity of microorganisms to antibiotics.

[Combined effect of ethonium and antibiotics on Pseudomonas aeruginosa].

The combined effect of ethonium and 5 antibiotics belonging to different groups was studied with 30 clinical strains of P. aeruginosa. A 2--8-fold increase in the activity of kanamycin and tetracycline against some strains was observed.

[Joint action of ethonium and antibiotics on gram-positive and gram-negative microorganisms].

The inhibitory effect of antibiotics and their combinations with ethonium was studied in vitro with 10 strains of Staph. aureus and 10 strains of E. coli, Sh.