Publications by authors named "Pirtea P"

Introduction: Since 2017, women with absolute uterine infertility due to Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome have been eligible to participate in a uterine transplantation clinical trial conducted by Foch Hospital in France. The aim of this study is to assess the psychological state of potential candidates, including recipients, their partners, and their living-related donors.

Material And Methods: Sixteen potential uterus transplant candidates, including recipients, partners, and living-related donors, participated in the study.

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Adenomyosis is a commonly encountered pathology in women of reproductive age and frequently coexists with infertility. The effect of adenomyosis on fertility, particularly on fertilisation and intracytoplasmic sperm injection outcomes, is not well understood. Various pretreatment modalities have been used to improve pregnancy rates and live birth outcomes; however, because of a lack of high-quality evidence, there is no clear consensus on the best pretreatment option.

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The countercurrent opinion given in this paper is that the optimal management of frozen embryo transfers (FET) is not a one-size-fits-all matter, but rather one that should be decided after considering all the various parameters and options. This choice should notably encompass patients' individual characteristics - including variable risks of obstetric complications - and weigh out the respective advantages of each FET option in each case. While there may be real advantages for natural-cycle FET in many cases, these need to be balanced against both practical and clinical issues.

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Purpose: The purpose of this study is to review patient experience with social fertility preservation (sFP), as compared to medical fertility preservation (mFP), in a context where sFP is fully reimbursed.

Methods: We conducted a retrospective cohort study involving patients who underwent oocyte cryopreservation for mFP between 2017 and 2023 and sFP between 2022 and 2023 at a large ART single center. Additionally, we surveyed patients undergoing sFP and mFP, regarding their experiences, intentions, awareness, and financial consideration.

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Adenomyosis is a benign condition commonly encountered in patients with infertility. While the definitive surgical management is hysterectomy, conservative surgical management is gaining attention in patients desiring future fertility. This review explores whether the surgical treatment of adenomyosis affects fertility outcomes for patients trying to conceive.

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Objective: This study aimed to review recent data that affected the clinical management of infertility associated with endometriosis.

Data Sources: We completed a PubMed review of all articles that included the following keywords: endometriosis, infertility, IVF, and ART.

Study Selection: A study was selected based on the pertinence of the topic addressed in relation to the study's set objectives.

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Objective: To investigate the impact of paternal age on cumulative live birth rate in ART.

Design: Retrospective single-center cohort study.

Patients: All female patients aged 18-43 years and male patients aged 18-60 years, who performed their first ART cycle between January 2018 and December 2020, were included.

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Article Synopsis
  • The purpose of the study was to investigate if different embryo culture conditions, like incubator type and oxygen levels, affect complications in babies born via in vitro fertilization (IVF).
  • Researchers conducted a systematic review of studies from 2008 to 2021, analyzing data on birthweight and preterm births, ultimately including 28 relevant studies.
  • The findings showed no significant differences in neonatal outcomes based on the evaluated culture conditions, indicating that more research is needed to ensure the safety of IVF methods for children's health.
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The improvements accomplished in assisted reproductive technology have emphasized more than ever the role played by chronological age, notably for predicting oocyte quality. Studies in cellular aging have directed research on telomere length measurements as possible markers of functional aging and, notably, female reproductive outcomes. Although further research is still needed, encouraging results are already available on the possibility that leucocyte telomere length may be a useful parameter for assessing reproductive potential in aging women.

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Article Synopsis
  • - Uterine Adenomyosis is a benign condition where endometrial-like tissue grows within the muscular layer of the uterus, causing pain and other symptoms, but there are no established guidelines for treatment options.
  • - A hysterectomy is the most definitive treatment, but for those wanting to maintain fertility, the levonorgestrel-IUD shows the best results among conservative options, while other treatments like GnRH antagonists and dienogest may be promising but need more research.
  • - This review examines current and emerging therapies for adenomyosis, utilizing a thorough literature search for various medical treatments and keywords relevant to the condition up to September 2022.
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Adenomyosis is a commonly diagnosed benign condition characterized by the presence of ectopic endometrial glands within the underlying myometrium. The most common presenting signs and symptoms are abnormal uterine bleeding, chronic pelvic pain, and infertility. The clinical relevance of this condition is evident in both medical and surgical care.

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McCune-Albright syndrome (MAS) is a rare genetic disease affecting multiple organs, including endocrine tissues. This endocrinopathy is sometimes responsible for infertility, as it may induce an independent functioning of the ovaries leading to anovulatory cycles. This case report describes the infertility journey of a 22-year-old female who had early puberty and irregular periods with high estrogen and progesterone levels, low FSH and LH (on day 3 of her menstrual cycle), and a multi-cystic right ovary.

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