[Theory and practice of electrospray crystallization in particle size reduction].

Nowdays, one of the most challenges for the researchers is the formulation of poorly water soluble drugs. Reduction of particle size of active agents to submicron range could result in a faster dissolution rate and higher bioavailability. Integration as crystallization process is an often used particle size decreasing technique.

[Use of a novel polymer, the in-situ gelling mucoadhesive thiolated poly(aspartic acid) in ophthalmic drug delivery].

The bioavailability of drugs used on mucosal surfaces can be increased by the use of mucoadhesive polymers. A new type of mucoadhesive polymers is the group of thiolated polymers with thiol group containing side chains. These polymers are able to form covalent bonds (disulphide linkages) with the mucin glycoproteins.

[Stability testing of meloxicam-containing microcomposites for inhalation].

The formulation of inhalation agents is a major challenge for the pharmaceutical technologist. The innovative inhalation formulations mean a new area of indication for active pharmaceutical ingredients. Among pulmonary preparations, dry powder inhalers (DPIs) can ensure stability, a high payload and patient convenience.

[Comparative study of crystallization processes in case of glycine crystallization].

In our work, the effect of crystallization methods and their parameters on the particle size, particle size-distribution and roundness were investigated in case of glycine crystallization. Three types of crystallization methods were applied according to the solubility results of the substance. In case of cooling crystallization, the effect of cooling and stirring rates were investigated.

[A applicability of sugar esters in hot-melt technology].

One of the most important tasks in pharmaceutical technology is the optimization of drug release. The hot-melt technology is an important method with which to modify the bioavailability. Sugar esters (SEs) have a wide range of HLB values (1-16).

[Use of mercury porosimetry, assisted by nitrogen adsorption in the investigation of the pore structure of tablets].

The microstructure of pharmaceutical solid dosage forms (porosity, pore volume-size distribution, specific surface area) can be investigated by different methods. Mercury porosimetry and nitrogen gas adsorption have been widely used to characterize the pore structure of tablets because these methods enable the determination of porosity and pore size distribution in one step. The two techniques are based on different physical interactions and cover specific ranges of pore size.