Publications by authors named "Piroska Bodi"
Objectives: The current European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) guidelines introduced the option to diagnose coeliac disease (CD) in children and adolescents without upper endoscopy if the defined criteria are met. The aim of our study was to evaluate how frequently paediatric gastroenterologists in Central Europe used the "no-biopsy" approach and how often the duodenal biopsy could have been omitted.
Methods: Medical records of patients aged < 19 years diagnosed with CD in 2016 from five European countries were analysed, focusing on levels of transglutaminase antibodies (TGA) at the time of diagnosis and on whether the diagnosis was confirmed using duodenal biopsy or "no-biopsy" approach.
Background & Aims: Prucalopride is a selective, high-affinity agonist of the 5-hydroxytryptamine (serotonin) receptor 4 that enhances motility in the gastrointestinal tract. We performed a multicenter, randomized, placebo-controlled, double-blind, phase 3 trial to evaluate the efficacy and safety of prucalopride in children (6 months to 18 years old) with functional constipation.
Methods: Children with functional constipation, based on the Rome III criteria, were given prucalopride (children ≤ 50 kg were given a 0.
Objectives: The aim of the study was to evaluate the incidence, baseline disease characteristics, and disease location based on the Paris classification in pediatric inflammatory bowel disease (IBD) in the Hungarian nationwide inception cohort. In addition, 1-year follow-up with therapy was analyzed.
Methods: From January 1, 2007 to December 31, 2009, newly diagnosed pediatric patients with IBD were prospectively registered.
Article Synopsis
- Mannose-binding lectin (MBL) is an immune system protein that may play a role in inflammatory bowel disease (IBD), and this study explored its deficiency in kids with IBD.
- The study involved 159 pediatric patients with IBD and 95 control subjects, measuring MBL levels and analyzing genetic markers and autoantibodies.
- Results showed significantly lower MBL levels in IBD patients, especially in those with Crohn's disease, indicating that low MBL may be linked to the disease's development.
Background: Significance of pancreatic autoantibodies determined by using exocrine pancreas (PAB) and antibodies against recombinant pancreas antigen (rPAB), as well as the importance of autoantibodies against goblet cells (GAB), is not known in pediatric patients with inflammatory bowel disease (IBD). Our aim was to determine the complex analysis of PAB, rPAB, GAB, antibodies against Saccharomyces cerevisiae, and perinuclear components of neutrophils in pediatric patients with IBD. Moreover, association with NOD2/CARD15 and disease phenotype was determined.
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- The study evaluated the role of esophagogastroduodenoscopy (EGD) in diagnosing upper gastrointestinal (UGI) involvement in children with inflammatory bowel disease (IBD), particularly focusing on Crohn's disease (CD) and ulcerative colitis (UC).
- During the study from 2007 to 2009, 420 children were diagnosed with IBD, with a prevalence of 63% CD and 31% UC, and EGD was performed on 56% of patients, revealing significant UGI lesions in many.
- The findings indicated that there is a notable UGI involvement in children with both CD and UC, with one-third of CD patients showing significant lesions, but EGD provided a definitive diagnosis for