Association between HIV-1 tropism and CCR5 human haplotype E in a Caucasian population.

Background: The influence of the diversity of CCR5 on HIV susceptibility and disease progression has been clearly demonstrated but how the variability of this gene influences the HIV tropism is poorly understood. We investigated whether CCR5 haplotypes are associated with HIV tropism in a Caucasian population.

Methods: We evaluated 161 HIV-positive subjects in a cross-sectional study.