Publications by authors named "Pires Ferreira Raphaela"
Front Physiol
November 2022
Article Synopsis
- Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder that leads to rapid aging and increased cardiovascular issues, but the exact causes of these heart problems are not well understood.
- This study used heart cells (cardiomyocytes) from a patient with HGPS to compare their characteristics to those of healthy heart cells, revealing abnormalities in mitochondrial structure and protein expression despite normal basic function.
- Findings suggest that the heart cells from HGPS patients have significant alterations in mitochondria and protein levels, shedding light on potential new mechanisms behind early heart aging in this syndrome.
