Publications by authors named "Piotr Surynt"
Article Synopsis
- The trimethylguanosine (TMG) cap is essential for the stability and processing of small nuclear RNAs (snRNAs), protecting them from degradation and aiding in their recognition by snurportin for nuclear import.
- Researchers conjugated TMG caps with Fluorescent Molecular Rotors (FMRs) to create new molecular probes, resulting in the synthesis of 34 modified TMG-FMR conjugates.
- These new compounds showed significantly stronger binding to snurportin compared to natural TMG caps, enhancing understanding of their interactions and revealing potential applications for visualizing protein-ligand interactions in live cells.
Background: Possible relationships between gut dysbiosis and breast cancer (BC) development and progression have been previously reported. However, the results of these metagenomics studies are inconsistent. Our study involved 88 patients diagnosed with breast cancer and 86 cancer-free control women.
View Article and Find Full Text PDFChemical modifications of the mRNA cap structure can enhance the stability, translational properties, and half-life of mRNAs, thereby altering the therapeutic properties of synthetic mRNA. However, cap structure modification is challenging because of the instability of the 5'-5'-triphosphate bridge and N7-methylguanosine. The Suzuki-Miyaura cross-coupling reaction between boronic acid and halogen compound is a mild, convenient, and potentially applicable approach for modifying biomolecules.
View Article and Find Full Text PDF