Publications by authors named "Piotr Sikora"

In this paper, the authors present a comparative analysis of the thermomechanical properties of plastics intended for machining before and after the annealing process. The research included the dynamic properties, thermal analysis and a study of the surface after machining. The dynamic properties were tested using the DMTA method.

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Purpose: We aimed to investigate the reactivity of retinal vessels to a flickering stimulus in patients with age-related macular degeneration (AMD) and healthy participants. We also assessed whether the parameters of retinal vessels are dependent on genetic predisposition.

Methods: A total of 354 patients with AMD and 121 controls were recruited for the study.

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This paper presents an analysis of the impact of modification of thermomechanical properties of polymer materials on the process of gear wheel machining on a CNC machine tool. Polymer materials Tecaflon (PVDA) and polyethylene (PE) were used for processing. The materials underwent thermal modification i.

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Article Synopsis
  • The study investigates the genetic factors contributing to age-related macular degeneration (AMD), focusing on variants in the CFH and ARMS2/HTRA1 genes among over 2000 genetic variants in AMD patients compared to controls.
  • A total of 296 AMD patients and 100 controls were analyzed using high-throughput sequencing, identifying three specific single nucleotide polymorphisms (SNPs) that significantly increase the odds of developing AMD.
  • The findings indicate that certain genotypes of CFH Y402H, ARMS A69S, and PRPH2 c.582-67T>A are strong risk factors for AMD, with the PRPH2 variant being a novel discovery linked to increased risk, warranting further investigation.
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Age-related macular degeneration (AMD) remains the leading cause of blindness in elderly people, but the pathophysiology of this disease is still largely unknown. We investigated the systemic expression of angiogenesis-regulating growth factors and selected miRNAs known to regulate angiogenesis in AMD patients. We also focused on possible correlations of their expression with the presence of CFH Y402H or ARMS A69S risk variants.

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This study describes the development of a new colorimetric assay to determine aromatic amino acid aminotransferase (ArAT) activity. The assay is based on the transamination of L-tryptophan in the presence of 2-oxoglutarate, which yields indole-3-pyruvate (IPyA). The amount of IPyA formed was quantified by reaction with the Salkowski reagent.

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