Publications by authors named "Piotr P Jaholkowski"
Objectives: Juvenile idiopathic arthritis (JIA) originates from a complex interplay between genetic and environmental factors. We investigated the association between seafood intake and dietary contaminant exposure during pregnancy and JIA risk, to identify sex differences and gene-environment interactions.
Methods: We used the Norwegian Mother, Father, and Child Cohort Study (MoBa), a population-based prospective pregnancy cohort (1999-2008).
Article Synopsis
- The basal ganglia are brain structures that play key roles in motor control, cognition, and emotion, and this study explored their genetic architecture through genome-wide association studies (GWAS) involving over 34,000 European participants.
- The research identified 72 genetic loci linked to basal ganglia volumes, with 50 of these being new discoveries, and highlighted a significant genetic overlap with disorders like Parkinson's and Alzheimer's disease.
- Findings suggest potential causal relationships where larger striatal volumes may contribute to Parkinson's disease risk, while certain genetic factors may influence the size of other basal ganglia components, advancing understanding of their implications in neurological conditions.
Bipolar disorder (BD) is a disabling disorder with heterogeneous symptom profiles and trajectories. Like many other neuropsychiatric disorders, clinical decision making related to diagnoses and choice of treatment is based on clinical assessments alone, and risk prediction for treatment success or resistance at an individual level remains sparse. An enormous effort to add biological markers to this risk prediction is ongoing.
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- * Researchers conducted a study that analyzed genetic data to uncover new risk loci for AN, identifying 58 novel loci specific to AN and 38 loci shared with major psychiatric disorders (like schizophrenia and bipolar disorder).
- * The findings indicate genetic overlap between AN and these psychiatric disorders, suggesting that shared characteristics may have a genetic foundation, and revealed involvement in numerous biological pathways, including important signaling mechanisms.
Background: Neuroinflammation is involved in the pathophysiology of Alzheimer's disease (AD), including immune-linked genetic variants and molecular pathways, microglia and astrocytes. Multiple Sclerosis (MS) is a chronic, immune-mediated disease with genetic and environmental risk factors and neuropathological features. There are clinical and pathobiological similarities between AD and MS.
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