Publications by authors named "Piotr Limanowka"
The P-Element-induced wimpy testis (PIWI) group of proteins plays a key role in RNA interference, particularly in the regulation of small non-coding RNAs. However, in recent years, PIWIs have gained attention in several diseases, mainly cancer. Therefore, the aim of this review was to evaluate current knowledge about the impact of PIWI proteins on cancer cells.
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- - The study investigates the expression levels of certain molecules (SEMA7A, SEMA4D, ADAM8, and ADAMTS10) in colorectal cancer (CRC) and how these relate to gene mutations (like KRAS and BRAF), microsatellite instability (MSI) status, and clinical features.
- - Results show increased levels of SEMA7A in tumors with BRAF mutations and higher ADAM8 expression in KRAS-mutant tumors, while ADAMTS10 is lower in PIK3CA-mutant CRC, but no significant differences were found based on MSI status.
- - The expressions of SEMA7A and SEMA4D are linked to various immune-related cytokines, highlighting
In recent years PIWI-interacting RNAs (piRNAs) have gained the interest of scientists, mainly because of their possible implications in cancer. Many kinds of research showed how their expression can be linked to malignant diseases. However, most of them evaluated the expression of piRNAs in tumor tissues.
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