PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate.

The PIP/PI3K network is a central regulator of metabolism and is frequently activated in cancer, commonly by loss of the PIP/PI(3,4)P phosphatase, PTEN. Despite huge research investment, the drivers of the PI3K network in normal tissues and how they adapt to overactivation are unclear. We find that in healthy mouse prostate PI3K activity is driven by RTK/IRS signaling and constrained by pathway feedback.

[Matrix metalloproteinase in development, physiology and degenerative processes of skeletal muscles].

Matrix metalloproteinase (MMP) are a large family of enzymes, active in both physiological and pathological processes of many tissues. These proteases are able to selectively degrade components of the Extracellular Matrix (ECM). In skeletal muscle enzymes included in the MMP family are involved in tissue remodeling process, playing a key role in myogenesis as well as in tissue remodeling and regeneration of muscle.

Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.

E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell division. It is unknown whether in addition to their 'core' cell cycle functions, E-type cyclins also perform unique tissue-specific roles.

Inflammatory response during slow- and fast-twitch muscle regeneration.

Introduction: Skeletal muscles are characterized by their unique ability to regenerate. Injury of a so-called fast-twitch muscle, extensor digitorum longus (EDL), results in efficient regeneration and reconstruction of the functional tissue. In contrast, slow-twitch muscle (soleus) fails to properly reconstruct and develops fibrosis.