Publications by authors named "Piotr Denew"
Introduction: Crooke's corticotropinomas are the unique cause of Cushing's disease. The majority of them are aggressive macroadenomas, refractory to conventional therapy, with a high recurrence rate. The aim of the study was the presentation, in relation to data from the literature, of a case of a patient with ACTH-dependent Cushing's syndrome caused by recurrent Crooke's cells corticotropinoma, who achieved 33-month complete remission after treatment with temozolomide (TMZ).
View Article and Find Full Text PDFArticle Synopsis
- Invasive tumors in Nelson's syndrome require aggressive treatment, and recent literature suggests that temozolomide (TMZ) may be effective against resistant adenomas.
- A case study of a 56-year-old woman showed that after multiple surgeries and other treatments for Cushing’s disease and subsequent tumor regrowth, TMZ was the only therapy that led to significant clinical improvement.
- This case represents the first documented instance in Poland of using TMZ for invasive corticotroph adenoma in Nelson's syndrome, supporting its potential as a treatment option.