On elastic deformations of cylindrical bodies under the influence of the gravitational field.

Background: Elastic deformations of gravitating cylindrical bodies are relevant for state-of-the-art photonic experiments, as they affect the physical properties of materials under consideration, impacting wave propagation. This is of key importance for a recently planned experiment to explore the influence of the gravitational field on entangled photons propagating in waveguides. The purpose of this work is to determine these elastic deformations as functions of temperature, pressure, and of the gravitational field.

On the Uniqueness of Schwarzschild-de Sitter Spacetime.

We establish a new uniqueness theorem for the three dimensional Schwarzschild-de Sitter metrics. For this, some new or improved tools are developed. These include a reverse Łojasiewicz inequality, which holds in a neighborhood of the extremal points of any smooth function.

Associations between the lipid profile and the development of hypertension in young individuals - the preliminary study.

Introduction: Hypertension is the leading direct cause of death in the world and one of the most important risk factors for cardiovascular disease (CVD). Elevated blood pressure (BP) often coexists with lipid disorders and is an additional factor that increases CV risk. Nowadays, we are able to distinguish low density lipoproteins (LDL) and high density lipoproteins (HDL) subfractions.

The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction.

The study aimed to assess the clinical significance of selected single nucleotide polymorphisms (SNPs) in patients with diastolic heart failure (HF): inflammation [-174 G/C Interleukin -6 (IL-6) rs1800795, tumor necrosis factor (TNF)-608 G/A rs1800629], fibrosis [Arg25Pro transforming growth factor β (TGF β) rs1800471], endothelial function [-786 T/C nitric oxide synthase (NOS) rs2070744], glucose and lipid metabolism [Pro12Ala peroxisome proliferator activated receptor (PPAR)γ rs1801282], and vitamin D metabolism [cytochrome P450 27B1 (CYP27B1) C-1260A].110 patients with HF with preserved and mid-range ejection fraction (HFpEF and HFmrEF) were recruited. GG homozygotes in 174 G/C of IL6 polymorphism are characterized by higher values of estimated glomerular filtration rate based on the study Modification of Diet in Renal Disease (eGFR MDRD) and C allele in the NOS polymorphism and AA profile in C-1260A of CYP27B1 polymorphism correlated with a lower eGFR (MDRD).

Non-singular space-times with a negative cosmological constant: II. Static solutions of the Einstein-Maxwell equations.

We construct infinite-dimensional families of non-singular static space-times, solutions of the vacuum Einstein-Maxwell equations with a negative cosmological constant. The families include an infinite-dimensional family of solutions with the usual AdS conformal structure at conformal infinity.

Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms.

Background And Aims: The effect of statin therapy on plasma adiponectin levels has not been conclusively studied. Therefore, we aimed to evaluate this effect through a systematic review and meta-analysis of available randomized controlled trials (RCTs).

Methods: Quantitative data synthesis was performed using a random-effects model with weighted mean difference (WMD) and 95% confidence interval (CI) as summary statistics.

Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.

Trimetazidine is a cytoprotective drug whose cardiovascular effectiveness, especially in patients with stable ischemic heart disease, has been the source of much controversy in recent years; some have gone so far as to treat the medication as a 'placebo drug' whose new side effects, such as Parkinsonian symptoms, outweigh its benefits. This article is an attempt to present the recent key studies, including meta-analyses, on the use of trimetazidine in chronic heart failure, also in patients with diabetes mellitus and arrhythmia, as well as in peripheral artery disease. This paper also includes the most recent European Society of Cardiology guidelines, including those of 2013, on the use of trimetazidine in cardiovascular disease.

Stationary Black Holes: Uniqueness and Beyond.

The spectrum of known black-hole solutions to the stationary Einstein equations has been steadily increasing, sometimes in unexpected ways. In particular, it has turned out that not all black-hole-equilibrium configurations are characterized by their mass, angular momentum and global charges. Moreover, the high degree of symmetry displayed by vacuum and electro-vacuum black-hole spacetimes ceases to exist in self-gravitating non-linear field theories.

Circadian changes in the hemostatic system in healthy men and patients with cardiovascular diseases.

The highest risk of cardiovascular events is in the morning, which may be associated with circadian changes in hemostasis. There is a 10% circadian variability in von Willebrand factor (vWF). Circadian periodicity has been noted for both the number of platelets and their aggregability.

Gluing initial data sets for general relativity.

We establish an optimal gluing construction for general relativistic initial data sets. The construction is optimal in two distinct ways. First, it applies to generic initial data sets and the required (generically satisfied) hypotheses are geometrically and physically natural.