Publications by authors named "Pintor L"

Exposure to multiple environmental stressors is a common occurrence that can affect organisms in predictable or unpredictable ways. Hypoxia and turbidity in aquatic environments are 2 stressors that can affect reproductive behaviors by altering energy availability and the visual environment, respectively. Here we examine the relative effects of population and the rearing environment (oxygen concentration and turbidity) on reproductive behaviors.

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Objective: Psychogenic non-epileptic seizures (PNES) mimic epileptic seizures without electroencephalographic correlation. Although classified as psychiatric disorders, their neurobiological or structural basis remains unclear. This study aimed to assess the prevalence and characteristics of MRI abnormalities in patients with PNES and those with comorbid epilepsy, compared to the general population, to enhance radiological evaluation and management.

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Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by a wide variety of symptoms, including frequent neurological and psychiatric symptomatology. Psychiatric symptoms encountered in SLE are frequent, between 37 and 95% of SLE patients present them, can appear at any point in the course of the disease and may include almost any type of disorder. We present the case of a 32-year-old woman who presented an SLE debut with catatonic symptoms without previous psychiatric history, representing a diagnostic and therapeutic challenge given that the diagnosis was initially wrongly filtered out and required up to three hospital admissions in a row to reach a proper diagnosis and treatment.

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Objective: The Epilepsy Self-Stigma Scale (ESSS) has been developed in Japan for patients with epilepsy (PWE). We aimed to validate the scale in Spanish and examine its validity and reliability.

Methods: The transcultural adaptation of the ESSS was conducted using translation and back-translation, along with pilot testing and an expert panel review.

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Freshwater organisms face a complex array of environmental stressors that can negatively affect endocrine function and subsequent fitness outcomes. Hypoxia and turbidity are two environmental stressors that are increasing due to human activities that could lead to endocrine disruption and reduced reproductive output. Our research addresses how hypoxia and elevated turbidity affect traits related to reproductive success, specifically sex hormone concentrations, investment in reproductive tissues and body size.

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Article Synopsis
  • - The study analyzed brain dynamics in 10 individuals with pharmacoresistant focal epilepsy and 30 healthy controls using resting-state functional MRI, focusing on how seizures start and spread.
  • - Findings revealed significant changes in global brain connectivity, with increased integration and flexibility, and specific regions showing paradoxical decreases in ignition within the seizure onset zone.
  • - The results contribute to a better understanding of epilepsy mechanisms and may help in creating diagnostic tools and therapies for seizure management.
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Article Synopsis
  • Psychotic disorders are more common in people with epilepsy, often needing quick treatment with antipsychotic medication, especially when access to psychiatrists is limited.
  • The manuscript reviews a case of a 45-year-old man with treatment-resistant epilepsy who developed a new psychotic episode, successfully treated with aripiprazole.
  • Early intervention for interictal psychotic episodes is crucial for better outcomes, and these cases typically respond well to lower doses of antipsychotic drugs compared to primary psychotic disorders.
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Although intraspecific trait variation is increasingly recognized as affecting ecosystem processes, few studies have examined the ecological significance of among-population variation in behavioral traits in natural ecosystems. In freshwater habitats, crayfish are consumers that can influence ecosystem structure (e.g.

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Objective: Psychogenic non-epileptic seizures (PNES) are complex clinical manifestations and misdiagnosis as status epilepticus remains high, entailing deleterious consequences for patients. Video-electroencephalography (vEEG) remains the gold-standard method for diagnosing PNES. However, time and economic constraints limit access to vEEG, and clinicians lack fast and reliable screening tools to assist in the differential diagnosis with epileptic seizures (ES).

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Background: Delirium is the most prevalent neuropsychiatric syndrome experienced by patients admitted to inpatient clinical units, occurring in at least 20% of medically hospitalized patients and up to 85% of those admitted to critical care units. Although current guidelines recommend the implementation of universal prevention strategies, the use of management strategies largely depends on constant surveillance and screening. This allows for the timely diagnosis and correction of its underlying causes and implementation of management strategies.

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Objective: Psychogenic nonepileptic seizures (PNES) are common imitators of epileptic seizures. Refractoriness to antiseizure medication hinders the differential diagnosis between ES and PNES, carrying deleterious consequences in patients with PNES. Psychiatric and psychological characteristics may assist in the differential diagnosis between drug-resistant epilepsy (DRE) and PNES.

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Delirium is the most prevalent psychiatric disorder in inpatient older people. Its presence is associated with higher rates of institutionalization, functional disability and mortality. This study aims to evaluate delirium in a hospitalized psychogeriatric population, focusing on which factors predict the appearance of delirium, the impact it generates and the diagnostic concordance between non-psychiatric physicians and psychiatrists.

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Introduction: Experts agree that there is a need for protocols to guide health professionals on how to best manage psychiatric comorbidities in patients with epilepsy (PWE). We aimed to develop practical recommendations for key issues in the management of depression in PWE.

Methods: This was a qualitative study conducted in four steps: (1) development of a questionnaire on the management of depression in PWE to be answered; (2) literature review and, if evidence from guidelines/consensus or systematic reviews was available, drafting initial recommendations; (3) a nominal group methodology for reviewing initial recommendations and formulating new recommendations on those issues without available evidence; and (4) drafting and approving the final recommendations.

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Article Synopsis
  • The study compares the effectiveness of two screening tools for major depression: the seven-item Hospital Anxiety and Depression Scale Depression subscale (HADS-D) and the total score of the 14-item version (HADS-T), which includes anxiety items and takes longer to complete.
  • An analysis of data from 20,700 participants revealed that both HADS-D and HADS-T had similar sensitivity and specificity for detecting major depression, with optimal cutoffs being ≥7 for HADS-D and ≥15 for HADS-T.
  • Overall, while both tools are accurate, the shorter HADS-D is preferred in most clinical settings due to its simplicity and time efficiency.
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Several psychotropic drugs, including antidepressants (AD), mood stabilizers, and antipsychotics (AP) have been suggested to have favorable effects in the treatment of COVID-19. The aim of this systematic review and meta-analysis was to collect evidence from studies concerning the scientific evidence for the repurposing of psychotropic drugs in COVID-19 treatment. Two independent authors searched PubMed-MEDLINE, Scopus, PsycINFO, and ClinicalTrials.

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Background: Predictive genetic tests are presently effective over several medical conditions, increasing the demand among patients and healthy individuals. Considering the psychological burden suspected familial dementia may carry on individuals, assessing personality, coping strategies, and mental health could aid clinicians in findings the appropriate time for delivering genetic test results and predict compliance regarding genetic counseling and expectations towards the genetic condition depending on the outcome.

Objective: To describe the psychiatric, psychological, and coping characteristics of a sample of Spanish individuals at risk of familial dementia before genetic test results were given.

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Background And Purpose: fMRI is a noninvasive tool for predicting postsurgical deficits in candidates with pharmacoresistant temporal lobe epilepsy. We aimed to test an adapted paradigm of the Rey Auditory Verbal Learning Test to evaluate differences in memory laterality indexes between patients and healthy controls and its association with neuropsychological scores.

Materials And Methods: We performed a prospective study of 50 patients with temporal lobe epilepsy and 22 healthy controls.

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The objectives of this study are to determine the influence of personality profile in patients with drug-resistant epilepsy on quality of life (QoL) after surgical treatment and compare the results with a non-surgical control group at the 1-year follow-up. We conducted a prospective, comparative, controlled study, including 70 patients suffering from drug-resistant epilepsy. Demographic, psychiatric, neurological, and psychological data were recorded at the baseline and at the 1-year follow-up.

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Crayfish (Decapoda: Astacoidea and Parastacoidea) are among the few animals that have stem cells in hemolymph, with the capacity to continuously produce differentiated neuronal structures throughout life. As the use of crayfish and other invertebrates increases in biomedical research, we must develop laboratory standards and guidelines for performing clinical procedures. This manuscript presents introductory protocols for anesthesia in crayfish during diagnostic imaging.

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An integrated transport service fare system, supported by an agreement for ticket revenue sharing among service providers, is an essential component to improve the experience of the users who can find single tickets for the integrated transport services they look for. A challenge is to find a model to share the revenue which all providers agree on. A solution is to adopt data-driven approaches where user-generated data are collected to extract information on the extent each transport service was used.

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Importance: Most evidence about efficacy and safety of antipsychotics in schizophrenia spectrum disorders relies on randomized clinical trials (RCTs). However, owing to their strict eligibility criteria, RCTs represent only a part of the real-world population (ie, unselected patients seen in everyday clinical practice), which may result in an efficacy-effectiveness gap.

Objective: To quantify the proportion of real-world individuals with schizophrenia spectrum disorders who would be ineligible for participation in RCTs, and to explore whether clinical outcomes differ between eligible and ineligible individuals.

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Objective: To determine changes in dimensions of personality in a sample of patients suffering from drug-resistant epilepsy at the 1-year follow-up following surgery, compared to non-surgically treated controls.

Methods: We conducted a prospective comparative controlled study, including drug-resistant epilepsy surgery candidates. Demographic, psychiatric, neurological, and psychological data were recorded.

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