Publications by authors named "Pinpin Jiang"
Article Synopsis
- This study investigates whether injecting miRNA-1 into the joints can slow down the progression of osteoarthritis (OA) in rats by targeting a specific protein called Ihh.
- Researchers collected knee cells from young rats, treated them with miR-1, and observed changes in various genes related to cartilage health through tests like RT-qPCR.
- The findings showed that miR-1 injections reduced inflammation and cartilage damage while promoting cartilage growth, suggesting it could be a potential treatment for OA.
[Meta-analysis of the role of fibular fixation in tibiofibular fractures].
Zhongguo Gu Shang
January 2024
Article Synopsis
- The study aims to evaluate the significance of fibular fixation in tibiofibular fractures through a comprehensive Meta-analysis of existing literature.
- Utilizing data from various databases, the researchers analyzed outcomes such as malrotation, non-union rates, and operation times between patients with and without fibula fixation.
- The results indicate that fixing the fibula during tibiofibular fracture treatment significantly lowers postoperative complications and enhances fracture healing, suggesting it is the more effective clinical approach.
Osteoarthritis (OA) is the second-commonest arthritis, but pathogenic and regulatory mechanisms underlying OA remain incompletely understood. Here, we aimed to identify the mechanisms associated with microRNA-1 (miR-1) treatment of OA in rodent OA models using a proteomic approach. First, N = 18 Sprague Dawley (SD) rats underwent sham surgery (n = 6) or ACL transection (n = 12), followed at an interval of one week by randomization of the ACL transection group to intra-articular administration of either 50 µL placebo (control group) or miR-1 agomir, a mimic of endogenous miR-1 (experimental group).
View Article and Find Full Text PDFEndochondral bone formation from the growth plate plays a critical role in vertebrate limb development and skeletal homeostasis. Although miR-1 is mainly expressed in the hypertrophic region of the growth plate during this process, its role in the endochondral bone formation is unknown. To elucidate the role of miR-1 in cartilage development, chondrocyte-specific transgenic mice with high expression of miR-1 were generated (Col2a1-Cre-ER-GFP-RFP-miR-1).
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