Publications by authors named "Pini C"
Article Synopsis
- The review explores how polyunsaturated fatty acids (PUFAs) are linked to various mental health disorders including dementia, schizophrenia, and anorexia nervosa by analyzing multiple types of studies.
- Evidence gathered indicates that PUFAs, especially ALA, EPA, and DHA, have neuroprotective properties that can improve brain function and behavior.
- A decrease in these fatty acids has been observed in populations with mental health disorders, suggesting that PUFA supplementation could serve as a promising treatment to help combat neuronal degeneration.
Article Synopsis
- SUVmax is a commonly used but limited parameter in assessing malignant lung nodules, with other metrics like lean body mass-adjusted values potentially offering more reliability.
- A study of 567 patients with suspected lung tumors showed that 91% had primary lung tumors, predominantly adenocarcinomas, yet SUVmax struggled to differentiate between benign and malignant lesions effectively.
- Survival analysis indicated that while SUVmax correlated with factors like overall survival and tumor characteristics, it lacked independent prognostic value, raising doubts about its sole reliance in clinical settings.
Article Synopsis
- Disease recurrence and resistance to radioiodine therapy pose significant challenges in managing differentiated thyroid cancer, particularly in patients with the TENIS syndrome, characterized by elevated thyroglobulin levels but negative radioiodine scans.
- A systematic review and meta-analysis evaluated the effectiveness of nuclear imaging, specifically [F]FDG PET/CT, on detecting thyroid cancer recurrence in TENIS patients, finding that it has a sensitivity of 87% and specificity of 76%.
- The study highlights the importance of [F]FDG PET/CT in guiding treatment decisions, especially as new radiopharmaceuticals continue to emerge for better detection of RAI-refractory cancer.
Article Synopsis
- Researchers did a review to update how good different types of PET scans are for finding and checking solid cancers (not brain cancers) using special medicines.
- They looked through many studies and found 64 helpful articles that show which types of PET scans work best for various cancers, like prostate and neuroendocrine tumors.
- The review found that some cancers, like esophageal cancer and certain types of lung cancer, don't have enough strong studies to help with diagnosis using PET scans.
Purpose: To investigate the accuracy of point-of-care ultrasound (PoCUS) in diagnosing acute appendicitis in children; to evaluate the concordance between PoCUS performed by a pediatric emergency physician (PedEm) and ultrasonography (US) performed by a radiologist; to draw a "learning curve."
Methods: We prospectively enrolled children aged 0-14 years old led to the Emergency Department of Regina Margherita Children's Hospital, from January 2021 to June 2021, with suspected acute appendicitis. PoCUS was performed by a single trained PedEm, blindly to the radiologist's scan.
From pixels to predictions: the scrying power of molecular imaging.
Eur J Nucl Med Mol Imaging
February 2024
Localized prostate cancer (PCa) can be treated with radical prostatectomy (RP). Up to 30% of patients undergoing this procedure experience biochemical recurrence (BCR), namely the rise in serum prostate-specific antigen (PSA) levels during the post-surgical follow-up, requiring further treatments and with the risk of severe disease progression. Currently, the most accurate imaging technique to confirm, detect, and locate disease relapses in BCR patients is prostate-specific membrane antigen (PSMA)-targeted PET, as recommended by international clinical guidelines.
View Article and Find Full Text PDFThe potential role of osteoporosis in unspecific [F]PSMA-1007 bone uptake.
Eur J Nucl Med Mol Imaging
December 2023
Aim: Unspecific bone uptake is one of the main limitations of PET imaging with some PSMA-targeting radiopharmaceuticals, especially with [F]PSMA-1007. We explored the potential association between osteoporosis and the occurrence of unspecific [F]PSMA-1007 bone uptake investigating markers which might correlate with bone mineral density.
Materials And Methods: We retrospectively analyzed treatment-naïve patients with a confirmed diagnosis of prostate adenocarcinoma who underwent staging [F]PSMA-1007 positron emission tomography (PET).
Purpose: IDH-wildtype (IDH-wt) diffuse gliomas with histological features of lower-grade gliomas (LGGs) are rare and heterogeneous primary brain tumours. [C]Methionine (MET) positron emission tomography (PET) is commonly used to evaluate glial neoplasms at diagnosis. The present study aimed to assess the prognostic value of MET PET in newly diagnosed, treatment naïve IDH-wt gliomas with histological features of LGGs.
View Article and Find Full Text PDFBackground: Intraoperative localisation of nodal disease in non-small cell lung cancer (NSCLC) can be challenging. Lymph node localisation via radiopharmaceuticals is used in many conditions; we tested the feasibility of this approach in NSCLC.
Methods: NSCLC patients were prospectively recruited.
Background: The value of Prostate Specific Membrane Antigen (PSMA) in thyroid carcinoma (TC) is still unknown. We aimed to test the potential complementary role of PSMA expression and 2-[F]fluoro-2-deoxy-D-glucose ([F]FDG) uptake on PET/CT as biomarkers for TC outcome prediction.
Materials And Methods: From a retrospective cohort of TC patients we selected those fulfilling the following inclusion/exclusion criteria: thyroidectomy in our Institution, available primary tumor tissue PSMA immunostaining, [F]FDG PET/CT and follow-up data.
Merkel Cell Carcinoma (MCC) is a rare primary cutaneous cancer with aggressive behaviour and poor prognosis. Although MCC cells express somatostatin receptors (SSTR), SSTR-targeted PET/CT is not routinely performed in clinical practice. In contrast, the use of [F]FDG PET/CT is more widespread and its prognostic role is well established.
View Article and Find Full Text PDFAdult-type diffuse gliomas are treated with a multimodality treatment approach that includes radiotherapy both in the primary setting, and in the case of progressive or recurrent disease. Radiation necrosis represents a major complication of radiotherapy. Recurrent disease and treatment-related changes are often indistinguishable using conventional imaging methods.
View Article and Find Full Text PDFThermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) have great potential for periodontal disease treatment, thanks to their ability to be liquid at room temperature and become viscous gels at body temperature. However, some problems, related to short in situ residence time, reduce their feasible clinical use.
View Article and Find Full Text PDFIntroduction: The present paper aims to systematically review the literature on COVID-19 vaccine-related findings in patients undergoing PET/CT.
Methods: The search algorithms included the following combination of terms: "PET" OR "positron emission tomography" AND "COVID"; "PET" OR "positron emission tomography" AND "COVID" AND "vaccination"; "PET" OR "positron emission tomography" AND "COVID", AND "autoimmune".
Results: We selected 17 articles which were assessed for quality and included in the systematic analysis.
Introduction And Aim: Diagnosis of hepatocellular carcinoma (HCC) often occurs when the disease is unresectable and therapeutic options are limited. The extent of disease and liver function according to Child-Pugh (C-P) classification are the main prognostic factors guiding clinicians in the management of HCC. The integration of albumin-bilirubin (ALBI) grade is emerging to assess liver function on account of its objectivity and reproducibility.
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