Elevated expression of microRNA-19a predicts a poor prognosis in patients with osteosarcoma.

MicroRNA (miR)-19a, a member of the miR-17-92 cluster, functions as an oncomiRNA in multiple kinds of cancers. However, its involvement in human osteosarcomas remains unclear. In this study, to analyze the expression pattern of miR-19a and to investigate its clinical implication in human osteosarcomas, quantitative reverse-transcription polymerase chain reaction was performed to detect expression levels of miR-19a in 166 self-pairs of osteosarcoma and noncancerous bone tissues.

[Effect of vascular endothelial cell growth factor on repair of bone defect with cortical bone allograft].

Objective: To study the effect of vascular endothelial cell growth factor (VEGF) on repair of bone defect with cortical bone allograft.

Methods: Forty five New Zealand white rabbits, weighted 2.5-3.