Preferential Perinatal Development of Skin-Homing NK1.1 Innate Lymphoid Cells for Regulation of Cutaneous Microbiota Colonization.

Proper immune cell development at early ontogenic stages is critical for life-long health. How resident immune cells are established in barrier tissues at neonatal stages to provide early protection is an important but still poorly understood question. We herein report that a developmentally programmed preferential generation of skin-homing group 1 innate lymphoid cells (ILC1s) at perinatal stages helps regulate early skin microbiota colonization.