Evaluating the impact of weight and center of mass on comfort in head-mounted displays.

This study investigates the impact of the weight and centre of mass (COM) position of Head-Mounted Displays (HMDs) on the subjective evaluation of users during prolonged wearing tasks. This study involved 88 participants completing 1860 sets of experiments under three conditions: sitting still, turning the head, and moving, providing subjective evaluations of wearing HMDs. A static torque testing device was used to simulate neck torque under flexion states.

Self-Assembled Nanoparticles with Well-Defined Oligosaccharide Promote Osteogenesis by Regulating Golgi Stress Response.

Osteoporosis, a prevalent disease characterized by low bone density and increased fracture risk, poses significant health challenges for the elderly. Current treatments offer short-term benefits but are limited by long-term efficacy and adverse effects, highlighting the need for new strategies. Chondroitin sulfate polysaccharides (CS), a major component of the bone matrix, are crucial for bone and cartilage health.

Immune regulation based on sex differences in ischemic stroke pathology.

Ischemic stroke is one of the world's leading causes of death and disability. It has been established that gender differences in stroke outcomes prevail, and the immune response after stroke is an important factor affecting patient outcomes. However, gender disparities lead to different immune metabolic tendencies closely related to immune regulation after stroke.

The role of proteoglycan form of DMP1 in cranial repair.

Background: The cranial region is a complex set of blood vessels, cartilage, nerves and soft tissues. The reconstruction of cranial defects caused by trauma, congenital defects and surgical procedures presents clinical challenges. Our previous data showed that deficiency of the proteoglycan (PG) form of dentin matrix protein 1 (DMP1-PG) could lead to abnormal cranial development.

Generation of functional oligopeptides that promote osteogenesis based on unsupervised deep learning of protein IDRs.

Deep learning (DL) is currently revolutionizing peptide drug development due to both computational advances and the substantial recent expansion of digitized biological data. However, progress in oligopeptide drug development has been limited, likely due to the lack of suitable datasets and difficulty in identifying informative features to use as inputs for DL models. Here, we utilized an unsupervised deep learning model to learn a semantic pattern based on the intrinsically disordered regions of ~171 known osteogenic proteins.

Tuning Crystallinity and Surface Hydrophobicity of a Cobalt Phosphide Cocatalyst to Boost CO Photoreduction Performance.

Photocatalytic CO conversion is a promising method to yield carbon fuels, but it remains challenging to regulate catalytic materials for enhanced reaction efficiency and tunable product selectivity. This study concerns the development of a facile and efficient thermal post-treatment method to improve the crystallinity and surface hydrophobicity of a cobalt phosphide (CoP) cocatalyst, which promotes the separation and transfer of photoexcited charge carriers, reinforces CO chemisorption, and weakens the H O affinity. Compared with pristine CoP, the optimal CoP-600 cocatalyst displays a 3.

Glycosylation of DMP1 promotes bone reconstruction in long bone defects.

The regeneration of bone defects is necessary for the successful healing. During the process of healing, callus plays crucial roles in providing the stable bone-reconstruction environment. The callus is consisted of various large molecules including collagen proteins, non-collagen proteins and proteoglycans (PGs), which are involved in maintaining mechanical strength and interacting with cytokines and grow factors in the injury sites.

When do defecation function and quality of life recover for patients with non-ostomy and ostomy surgery of rectal cancer?

Background: Rectal cancer (RC) surgery often results in permanent colostomy, seriously limiting the quality of life (QOL) in patients in terms of bowel function. This study aimed to examine defecation function and QOL in RC patients who underwent non-ostomy or ostomy surgery, at different time-points after surgery.

Methods: In total, 82 patients who underwent an ostomy and 141 who did not undergo an ostomy for the treatment of RC at our colorectal surgery department between January 2013 and January 2015 were enrolled.

Molecular Junctions on Polymeric Carbon Nitrides with Enhanced Photocatalytic Performance.

Molecular catalysts (MC), namely homogeneous catalysts, have demonstrated great promise for efficient solar-to-chemical energy conversion in the hybrid system. However, the poor interfacial interaction between MC and photosensitizers (PS) impedes the efficient and fast interfacial electron transfer. To promote interfacial communication between PS and MC, a proof-of-concept method was developed for the combination of polymeric carbon nitride (PCN) PS with bipyridine cobalt [Co(bpy) ] MC by covalent bonds, creating molecular junctions to promote interfacial electron transfer as confirmed by transient photoluminescence lifetime and electrochemical measurements.

Prognostic and Therapeutic Significance of Adhesion-regulating Molecule 1 in Estrogen Receptor-positive Breast Cancer.

Introduction: Adhesion-regulating molecule 1 (ADRM1) is a polyubiquitin receptor on the 26S proteasome. ADRM1 is upregulated in many cancers. In this study, we evaluated the potential prognostic and predictive value of ADRM1 in breast cancer.

Toxicologic evaluation of repetitive 4-week intravenous injections of midkine antisense oligonucleotide nanoliposomes in rats.

Midkine antisense oligonucleotide (MK-ASODN) nanoliposomes have previously been shown to have inhibitory activity against hepatocellular carcinoma growth. Herein we report the 4-week sub-chronic toxicity of MK-ASODN nanoliposomes in SD rats. The adverse effects included loss of body weight gain and food consumption, peri-rhinal bleeding, piloerection, peri-anal filth, and kidney, liver, spleen, thymus, lung, and injection site lesions at high doses.

Comparison of the eighth version of the American Joint Committee on Cancer manual to the seventh version for colorectal cancer: A retrospective review of our data.

Aim: To analyze the survival trends in colorectal cancer (CRC) based on the different classifications recommended by the seventh and eighth editions of the American Joint Committee on Cancer staging system (AJCC-7 and AJCC-8).

Methods: The database from our institution was queried to identify patients with pathologically confirmed stage 0-IV CRC diagnosed between 2006 and 2012. Data from 2080 cases were collected and 1090 cases were evaluated through standardized inclusion and exclusion criteria.

Defluoridation investigation of Yttrium by laminated Y-Zr-Al tri-metal nanocomposite and analysis of the fluoride sorption mechanism.

In this study, a laminated nanocomposite of Y-Zr-Al with significantly high surface area of 256.6 m/g was successfully prepared, and was used to investigate the defluoridation performance of sorbent based on Yttrium. The composite showed high fluoride sorption performance, especially at low F concentration conditions.

The role of tissue and serum carcinoembryonic antigen in stages I to III of colorectal cancer-A retrospective cohort study.

Purpose: Tissue carcinoembryonic antigen (t-CEA) and serum carcinoembryonic antigen (s-CEA) expression profiles are the most useful tumor markers for the diagnosis and evaluation of colorectal cancer (CRC) worldwide; however, their roles in CRC progression remain controversial. This study aimed to compare the prognostic values of both s-CEA and t-CEA in CRC.

Methods: A total of 517 patients from January 2006 to December 2010 with stages I-III CRC were retrospectively examined, with 5-year postoperative follow-up and death as end-points.

LiCl as Phase-Transfer Catalysts to Synthesize Thin Co P Nanosheets for Oxygen Evolution Reaction.

Inorganic salts have been widely studied as templates for the synthesis of 2D layer structures. However, these salts normally can only serve as templates without any catalytic activity. Here, we report that LiCl used for the synthesis of ultrathin nanosheets not only serves as template for the synthesis of ultrathin Co P nanosheets with a thickness of 0.

MiR-1260b promotes the migration and invasion in non-small cell lung cancer via targeting PTPRK.

Objective: Non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases which cause most of cancer-related deaths globally. As our previous study discovered miR-1260b can be regarded as a specific signature for metastasis in NSCLC patients. However, the molecular mechanisms of miR-1260b underlying NSCLC progression and metastasis remain dismal.

Giant Hollow Heterometallic Polyoxoniobates with Sodalite-Type Lanthanide-Tungsten-Oxide Cages: Discrete Nanoclusters and Extended Frameworks.

The first series of niobium-tungsten-lanthanide (Nb-W-Ln) heterometallic polyoxometalates {Ln W O (H O) (Nb O ) } (Ln=Y, La, Sm, Eu, Yb) have been obtained, which are comprised of giant cluster-in-cluster-like ({Ln W }-in-{Nb }) structures built from 12 hexaniobate {Nb O } clusters gathered together by a rare 24-nuclearity sodalite-type heterometal-oxide cage {Ln W O (H O) }. The Nb-W-Ln clusters present the largest multi-metal polyoxoniobates and a series of rare high-nuclearity 4d-5d-4f multicomponent clusters. Furthermore, the giant Nb-W-Ln clusters may be isolated as discrete inorganic alkali salts and can be used as building blocks to form high-dimensional inorganic-organic hybrid frameworks.

Decorating CoP and Pt Nanoparticles on Graphitic Carbon Nitride Nanosheets to Promote Overall Water Splitting by Conjugated Polymers.

The splitting of water into H and O using solar energy is one of the key steps in artificial photosynthesis for the future production of renewable energy. Here, we show the first use of CoP and Pt nanoparticles as dual co-catalysts to modify graphitic carbon nitride (g-C N ) polymer to achieve overall water splitting under visible light irradiation. Our findings demonstrate that loading dual co-catalysts on delaminated g-C N imparts surface redox sites on the g-C N nanosheets that can not only promote catalytic kinetics but also promote charge separation and migration in the soft interface, thus improving the photocatalytic efficiency for overall water splitting.

Development of hybrid-type modified chitosan derivative nanoparticles for the intracellular delivery of midkine-siRNA in hepatocellular carcinoma cells.

Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Most of the patients with HCC lose the surgical opportunity at the time of diagnosis. Some novel therapeutic modalities, like gene therapy, are promising for the treatment of HCC.