Galectin-3 in metabolic disorders: mechanisms and therapeutic potential.

Galectin-3 (Gal3), a β-galactoside-binding lectin, is expressed predominantly in immunological and inflammatory cells. Gal3 expression is elevated in metabolic diseases, including obesity, diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD), and plays an important role in the progression of these diseases. In this review, we summarize the structure and post-translational modifications of Gal3 and the cellular functions of Gal3 according to its subcellular localization.

Spatial Conformation Engineering of Aromatic Ketones for Highly Efficient and Stable Perovskite Solar Cells.

Carbonyl-containing materials employed in state-of-the-art hybrid lead halide perovskite solar cells (PSCs) exhibit a strong structure-dependent electron donor effect that predominates in defect passivation. However, the impact of the molecular spatial conformation on the efficacy of carbonyl-containing passivators remains ambiguous, hindering the advancement of molecular design for passivating materials. Herein, we show that altering the spatial torsion angle of aromatic ketones from twisted to planar configurations, as seen in benzophenone (BP, 27.

LMAN2 Promotes Breast Cancer Tumorigenesis and Drug Resistance by Interacting With MAPK9 via Activation of the MAPK Pathway.

Introduction: Breast cancer (BC) is the most prevalent malignancy among women worldwide. Lectin, mannose-binding 2 (LMAN2) is a cargo receptor engaged in the transport and sorting of glycoproteins. Despite its ubiquity, the function and underlying mechanisms of LMAN2 in BC continue to elude understanding.

PKC inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability.

Protein kinase C (PKC) regulates diverse biological functions of cancer cells and is a promising therapeutic target. However, clinical trials of PKC-targeted therapies have not yielded satisfactory results. Recent studies have also indicated a tumor-suppressive role of PKCs unclear molecular mechanisms.

Land use modeling and carbon storage projections of the Bosten Lake Basin in China from 1990 to 2050 across multiple scenarios.

Given the escalating issue of global climate change, it is imperative to comprehend and quantify the effects of land use change on carbon storage (CS), which pertains not only to the preservation of ecosystem functions but also directly influences the equilibrium and stability of the global carbon cycle. This study examines the correlation between CS and land use change, forecasts the future spatial distribution of CS, and offers a reference for the rational planning of watershed space. Focusing on the Bosten Lake Basin of Xinjiang in China, employing the land use simulation (PLUS) model and the integrated valuation of ecosystem services and trade-offs (InVEST) model to forecast the spatial distribution of carbon stocks across three developmental scenarios, while also examining the shift in the center of gravity of CS and the autocorrelation of their spatial distribution.

Utilizing Waste Biomass from Agricultural and Forestry Sustainable Resources: Biomass Conversion to Functional Adsorbent Material for Efficient Removal of Total Phosphate in Practical Water.

The promotion of the utilization of waste agricultural and forestry resources (AFRs) as a means of combating environmental pollution represents an advanced and necessary development approach with the potential to achieve sustainable development. In this work, an advanced adsorbent with a functional Mg-Al bimetallic layer was prepared using waste sawdust biomass (WSD) as a raw material. The layer serves as the primary active component for adsorbing total phosphate from both simulated and real wastewater.

S-palmitoylation of MAP kinase is essential for fungal virulence.

S-palmitoylation is an important reversible protein post-translational modification in organisms. However, its role in fungi is uncertain. Here, we found the treatment of the rice false fungus with S-palmitoylation inhibitor 2 BP resulted in a significant decrease in fungal virulence.

Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population.

The prevalence of type-2 diabetes mellitus (T2DM) has increased over 10-fold in the past 40 years in China, which now has the largest T2DM population in the world. Insulin resistance and β-cell dysfunction are the typical features of T2DM. Although both factors play a role, decreased β-cell function and β-cell mass are the predominant factors for progression to T2DM.

Defect Passivation of Mn-Doped CsPbX(X=Cl,Br) Perovskite Nanocrystals as Electrocatalyst for Overall Water Splitting.

Mn doping has been used to improve the physical chemistry of lead halide perovskite nanocrystals such as CsPbX, where X is a halogen ion. In this paper, a two-phase method for Mn-doped CsPbX nanosheets (where X=Br, Cl), namely water-hexane system, is reported. Compared to conventional catalyst arrays, the band gap of CsPbBr nanocrystalline is easily tuned, the carrier diffusion distance is remote, the band edge position of the band structure is favorable for a wide range of electrocatalytic redox reactions, and the catalytic active site is maximally exposed, providing a larger electrolyte contact area.

Machine learning-based discrimination of unipolar depression and bipolar disorder with streamlined shortlist in adolescents of different ages.

Background: Variations in symptoms and indistinguishable depression episodes of unipolar depression (UD) and bipolar disorder (BD) make the discrimination difficult and time-consuming. For adolescents with high disease prevalence, an efficient diagnostic tool is important for the discrimination and treatment of BU and UD.

Methods: This multi-center cross-sectional study involved 1587 UD and 246 BD adolescents aged 12-18.

Analysis of changes in nutritional compounds of dried yellow chili after different processing treatments.

Dried yellow chili is highly appreciated by consumers due to its excellent quality and flavor. The quality of products is determined by the drying and storage methods. In this study, dried yellow chilis were processed by natural air drying and hot air drying methods and then stored under three conditions: ambient temperature, ambient temperature with light avoidance, and at 10 °C with light avoidance for 12 months.

Unraveling the Role of Electron-Withdrawing Molecules for Highly Efficient and Stable Perovskite Photovoltaics.

Electron-withdrawing molecules (EWMs) have exhibited remarkable efficacy in boosting the performance of perovskite solar cells (PSCs). However, the underneath mechanisms governing their positive attributes remain inadequately understood. Herein, we conducted a comprehensive study on EWMs by comparing 2,2'-(2,5-cyclohexadiene-1,4-diylidene) bismalononitrile (TCNQ) and (2,3,5,6-tetrafluoro-2,5-cyclohexadiene-1,4-diylidene) dimalononitrile (F4TCNQ) employed at the perovskite/hole transport layer (HTL) interfaces.

Zero-Background Dual-Mode Closed Bipolar Electrode Electrochemiluminescence Biosensor Based on ZnCoN-C Potential Regulation for Ultrasensitive Detection of Ochratoxin A.

In this work, the relationship between electrochemiluminescence (ECL) signal and driving voltage was first studied by self-made reduced and oxidized closed bipolar electrodes (CBPEs). It was found that when the driving voltage was large enough, the maximum ECL signals for the two kinds of CBPEs were the same but their required drive voltages were different. Zinc cobalt nitrogen doped carbon material (ZnCoN-C) had an outstanding electric double layer (EDL) property and conductivity.

Metabolome analysis of egg yolk and white following dietary supplementation with Ampelopsis grossedentata extract.

Eggs are recognized for their rich nutrient profile, providing essential proteins and lipids with notable functional properties. This study examines the effects of incorporating Water Extract of Ampelopsis grossedentata (WEA) into poultry feed on egg quality, focusing on lipid content, choline, L-carnitine levels, and flavonoid compound deposition. Our results show significant increases in essential amino acids, flavonoids, and other bioactive compounds in eggs from WEA-treated hens, suggesting enhanced cardiovascular, antioxidant, and anti-inflammatory benefits.

Association between triglyceride-glucose index and sarcopenia in patients with chronic inflammatory airway disease.

Objective: This research sought to explore the association between the triglyceride-glucose (TyG) index and the risk of sarcopenia in patients with chronic inflammatory airway disease (CIAD).

Methods: Data were obtained from the National Health and Nutrition Examination Survey 2011-2018. Grouping was performed using TyG index tertiles and multiple logistic regression was employed to assess the correlation between TyG levels and the risk of sarcopenia.

Glycnsisitin A: A promising bicyclic peptide against heart failure that facilitates TFRC-mediated uptake of iron in cardiomyocytes.

Zhigancao decoction is a traditional prescription for treating irregular pulse and palpitations in China. As the monarch drug of Zhigancao decoction, the bioactive molecules of licorice against heart diseases remain elusive. We established the HRESIMS-guided method leading to the isolation of three novel bicyclic peptides, glycnsisitins A-C (-), with distinctive C-C and C-O-C side-chain-to-side-chain linkages from the roots of (Licorice).

The spatial pattern of competition based on competitive exclusion theory.

Introduction: Population-level competition and spatial patterns may explain the role of competitive exclusion in communities, which is important for vegetation restoration and biodiversity conservation.

Methods: We analyzed the competitive intensity, spatial patterns, and renewal of Oliv. forests in the Tarim River Basin using the Hegyi competition index and spatial point pattern analysis in a completely random model with different habitats and different forest ages.