Causal association between hypothyroidism and obstructive sleep apnea: A bidirectional 2-sample Mendelian Randomization study.

Although previous epidemiological studies have investigated the correlation between hypothyroidism and obstructive sleep apnea (OSA), the results are controversial and conflicting. Therefore, we used a bidirectional 2-sample Mendelian randomization (MR) approach to infer the causal relationship between hypothyroidism and OSA. We performed a bidirectional 2-sample MR analysis to infer the causal relationship between hypothyroidism and OSA using genome-wide association study (GWAS) data.

Bronchoalveolar Lavage Fluid Microbiota is Associated with the Diagnosis and Prognosis Evaluation of Lung Cancer.

Unlabelled: The gut microbiota and cancer have been demonstrated to be closely related. However, few studies have explored the bronchoalveolar lavage fluid (BALF) microbiota in patients with lung cancer (LC), specifically the microbiota related to progression-free survival (PFS) in LC. A total of 216 BALF samples were collected including 166 LC and 50 benign pulmonary disease (N-LC) samples, and further sequenced using 16S rRNA amplicon sequencing.

SPHK1 Promotes Pancreatic Cancer Lymphangiogenesis Through the Activation of ERK in LECs.

Lymphatic metastasis is related to an unsatisfactory prognosis in pancreatic cancer. Sphingosine kinase 1 (SPHK1) is an oncogene in cancer. However, the potential effect of SPHK1 on the lymphangiogenesis of pancreatic cancer is little known.

CSF3 aggravates acute exacerbation of pulmonary fibrosis by disrupting alveolar epithelial barrier integrity.

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive respiratory disorder characterized by poor prognosis, often presenting with acute exacerbation. The primary cause of death associated with IPF is acute exacerbation of IPF (AE-IPF). However, the pathophysiology of acute exacerbation has not been clearly elucidated yet.

Study on the Thermal Stabilizing Process of Layered Double Hydroxides in PVC Resin.

Poly(vinyl chloride) (PVC) is widely used in various fields and requires the use of thermal stabilizers to enhance its thermal stability during processing because of its poor thermal stability. Layered double hydroxides (LDHs) are widely considered to be one kind of highly efficient and environmentally friendly PVC thermal stabilizer. To investigate the thermal stabilizing process of layered double hydroxides (LDHs) in PVC resin, PVC and MgAl-LDHs powders with different interlayer anions (CO, Cl, and NO) were physically mixed and aged at 180 °C.

Self-Generated Organic Acid System for Acid Fracturing in an Ultrahigh-Temperature Carbonate Reservoir.

As an important part of acid fracturing technology for the carbonate reservoir, the performance of the acid system directly affects the stimulation effect. In view of the current problems of an acid fluid system in an ultrahigh-temperature carbonate reservoir, such as fast acid-rock reaction, short effective action distance, and difficulty maintaining the conductivity of acid etching fractures, an experimental study on the self-generated organic acid system was carried out. The results showed that acetic anhydride and ethyl acetate, which had a strong acid generating ability, were suitable for the parent acid types of self-generated organic acids.

Experimental Study on the Diversion Characteristic of a Viscous Fluid in a Heterogeneous Reservoir.

As a typical feature of a reservoir, heterogeneity is the main reason for low oil recovery and the poor effect of acidizing measures. Diversion is the main measure to improve the acidizing effect. Over the years, technological progress has mainly focused on the material development of diverting agents.

Significance of interstitial fibrosis and p16 in papillary thyroid carcinoma.

We enrolled 264 patients with papillary thyroid carcinoma (PTC). We performed immunohistochemical detection of p16 and determined the degree of interstitial fibrosis (IF). The expression of p16 was associated with pathological tumor-node-metastasis (pTNM) stage and age (p < 0.

Numerical Modeling of Fracture Height Propagation in Multilayer Formations Considering the Plastic Zone and Induced Stress.

Hydraulic fracturing and acid fracturing are very effective stimulation technologies and are widely used in unconventional reservoir development. Fracture height, as an essential parameter to describe the geometric size of a fracture, is not only the input parameter of two-dimensional fracturing models but also the output parameter of three-dimensional fracturing models. Accurate prediction of fracture height growth can effectively avoid some risks.

Experimental Study on the Autogenic Acid Fluid System of a High-Temperature Carbonate Reservoir by Acid Fracturing.

As an important part of the acid fracturing process of carbonate reservoir, the performance of acid fracturing working fluid directly affects the stimulation effect of oil wells. In this paper, formaldehyde (agent A) and ammonium chloride (agent B) were used as the matrix. Several aldehydes with different volume ratios were prepared.

Successful Treatment of an Elderly Patient With Combined Small Cell Lung Cancer Receiving Anlotinib: A Case Report.

Combined small-cell lung cancer (C-SCLC) is a relatively rare subtype of SCLC and is defined by the combination of SCLC and any elements of non-small-cell lung carcinoma. Anlotinib is a novel oral multitarget tyrosine kinase inhibitor that led to significant improvements in progression-free survival and overall survival in third-line therapy of advanced SCLC in the ALTER1202 study. Antiangiogenic therapy with anlotinib in C-SCLC has not previously been reported.

Elevated levels of interleukin-35 and interleukin-37 in adult patients with obstructive sleep apnea.

Background: Systemic inflammation has a critical role in the pathogenesis of obstructive sleep apnea (OSA). Interleukin (IL)-35 and IL-37 have been identified as novel immune-modulating cytokines with anti-inflammatory activities in numerous types of inflammatory disease. The present study aimed to examine the serum levels of IL-35 and IL-37 in patients with OSA, and to investigate their associations with the severity of OSA.

Treatment of maternal anemia by using oral iron drugs combined with diet therapy.

Iron deficiency anemia is a common nutritional deficiency disease in women during pregnancy, mainly due to the increased iron requirements of pregnant women and fetuses, resulting in a lack of iron elements necessary for the production of red blood cells, resulting in a decrease in the number of red blood cells and the symptoms of anemia; Causes chronic fetal hypoxia and affects the normal development of some important organs of the fetus. This article explores the clinical value of oral iron drugs combined with diet therapy for maternal anemia. Observed the changes of hemoglobin (Hb), red blood cell count (RBC), average hemoglobin concentration (McHc), serum iron (SI), transferrin saturation (TS) and other indicators of pregnant women before and after treatment and the differences in pregnancy outcomes.

Whipping properties and stability of whipping cream: The impact of fatty acid composition and crystallization properties.

In this study, five fats (hydrogenated palm kernel oil, HPKO-A and HPKO-B; refined vegetable oils, RVO-A and RVO-B; transesterification oil, TO) were used to prepare whipping creams. HPKO-A and RVO-A which rich in lauric and myristic acids facilitated the formation of small crystals and dense crystal network, while higher stearic acid content of HPKO-B formed large spherical crystals. The richness in palmitic acid (RVO-B and TO) and oleic acid (TO) led to the formation of weak crystal network.

The Tetracentron genome provides insight into the early evolution of eudicots and the formation of vessel elements.

Background: Tetracentron sinense is an endemic and endangered deciduous tree. It belongs to the Trochodendrales, one of four early diverging lineages of eudicots known for having vesselless secondary wood. Sequencing and resequencing of the T.

Characterization of the lung microbiome and exploration of potential bacterial biomarkers for lung cancer.

Background: Emerging evidence has suggested that dysbiosis of the lung microbiota may be associated with the development of lung diseases. However, the interplay between the lung microbiome and lung cancer remains unclear. The aim of the present study was to evaluate and compare differences in taxonomic and derived functional profiles in the lung microbiota between lung cancer and benign pulmonary diseases.

Calcitonin Gene-Related Peptide Attenuates LPS-Induced Acute Kidney Injury by Regulating Sirt1.

BACKGROUND Acute kidney injury (AKI) caused by sepsis is a very dangerous clinical complication. This study explored the effects of calcitonin gene-related peptides (CGRP) on AKI and its mechanisms. MATERIAL AND METHODS We cultured renal proximal tubular epithelial cells (HK-2 cells) and induced AKI models using LPS.

Serum periostin and TNF-α levels in patients with obstructive sleep apnea-hypopnea syndrome.

Purpose: Obstructive sleep apnea-hypopnea syndrome (OSAHS) may cause pulmonary diseases, and periostin plays an important role on the development of pulmonary diseases. In addition, periostin and pro-inflammatory cytokine TNF-α can regulate each other in vivo. This study aimed to observe the changes of serum periostin and TNF-α levels in patients with OSAHS compared with healthy volunteers and to investigate their correlation.

Synthesis and characterization of a novel, pH-responsive, bola-based dynamic crosslinked fracturing fluid.

Fracturing fluids are important media for hydraulic fracturing. Typically, the fluids are gelled using a polymeric gelling agent. Technological improvements over the years have focused primarily on improving the rheological performance, thermal stability, and the clean-up of crosslinked gels.

A reservoir-damage-free encapsulated acid dually controlled by hydrogen ion concentration and temperature.

Oil and gas exploration and development extends from medium-low temperatures to high and ultra-high temperatures with the development of the oil and gas industry. High-temperature deep carbonate reservoir acid fracturing has introduced more stringent requirements, a slower chemical reaction rate and excellent dissolution performance of acid systems, which means that the acid system should still have a certain dissolution ability above 135 °C. A novel water-soluble encapsulated acid (EA), dual controlled by hydrogen ion concentration and temperature, was developed to exploit ultra-high-temperature carbonate reservoirs.

The Microstructure and Mechanical Properties of Multi-Strand, Composite Welding-Wire Welded Joints of High Nitrogen Austenitic Stainless Steel.

A multi-strand composite welding wire was applied to join high nitrogen austenitic stainless steel, and microstructures and mechanical properties were investigated. The electrical signals demonstrate that the welding process using a multi-strand composite welding wire is highly stable. The welded joints are composed of columnar austenite and dendritic ferrite and welded joints obtained under high heat input and cooling rate have a noticeable coarse-grained heat-affected zone and larger columnar austenite in weld seam.

Duplication and diversification of lectin receptor-like kinases (LecRLK) genes in soybean.

Lectin receptor-like kinases (LecRLKs) play important roles in plant development and stress responses. Although genome-wide studies of LecRLKs have been performed in several species, a comprehensive analysis including evolutionary, structural and functional analysis has not been carried out in soybean (Glycine max). In this study, we identified 185 putative LecRLK genes in the soybean genome, including 123 G-type, 60 L-type and 2 C-type LecRLK genes.

Origin and diversification of leucine-rich repeat receptor-like protein kinase (LRR-RLK) genes in plants.

Background: Leucine-rich repeat receptor-like protein kinases (LRR-RLKs) are the largest group of receptor-like kinases in plants and play crucial roles in development and stress responses. The evolutionary relationships among LRR-RLK genes have been investigated in flowering plants; however, no comprehensive studies have been performed for these genes in more ancestral groups. The subfamily classification of LRR-RLK genes in plants, the evolutionary history and driving force for the evolution of each LRR-RLK subfamily remain to be understood.