A Deferoxamine-Loaded Microneedle Patch Enhances Healing of Radiation-Induced Skin Injury: Potential Involvement of Ferroptosis.

Radiation-induced skin injury (RSI) presents a significant challenge in wound care due to its complex pathophysiology, which includes increased oxidative stress, impaired angiogenesis, and delayed re-epithelialization. Transcriptomic analysis reveals significant alterations in genes associated with the ferroptosis pathway following radiation exposure. In this study, we introduce microneedles composed of silk fibroin hydrogel loaded with deferoxamine (SF+MNs+DFO) to inhibit ferroptosis.

Dual-Task Optimization Method for Inverse Design of RGB Micro-LED Light Collimator.

Miniaturized pixel sizes in near-eye digital displays lead to pixel emission patterns with large divergence angles, necessitating efficient beam collimation solutions to improve the light coupling efficiency. Traditional beam collimation optics, such as lenses and cavities, are wavelength-sensitive and cannot simultaneously collimate red (R), green (G), and blue (B) light. In this work, we employed inverse design optimization and finite-difference time-domain (FDTD) simulation techniques to design a collimator comprised of nano-sized photonic structures.

Non-static Stafne bone cavity: a case report.

Stafne bone cavity, also known as static bone cavity, is a rare bony defect on the lingual side of the mandible. It rarely shows progressive changes, and requires only follow-up bservation. This article described a case of progressive enlargement of a Stafne bone cavity and analyzed the causes of its progress by reviewing relevant literature.

Cu- and S-Doped Heteropolyacid CoMo as Electrocatalysts for Efficient Hydrogen Evolution.

This study employed polyoxometalate CoMo as a precursor and a two-step method to prepare carbon cloth-supported CuS-CoS-MoS materials. The morphology and structure of the materials were characterized using XRD, XPS, SEM, TEM, and other techniques. Interestingly, changes in the reducing gas during the calcination process could adjust the product morphology, thereby altering catalytic activity.

Enhanced Transconjunctival Lower Blepharoplasty: A Novel Method for Intraorbital Fat Transposition and Stabilization.

Background: The evolution of lower blepharoplasty has shifted from simply removing of orbital septum fat to smoothing of the lid-cheek junction through fat repositioning. This paper adopts a novel technique to transpose and stabilize intraorbital fat during transconjunctival lower blepharoplasty. The tear trough and nasal alar base were filled to correct the pouch while ensuring the blood supply of the fat flap.

Interleukin-33 links asthma to alopecia areata: Mendelian randomization and mediation analysis.

Objective: The objective of this study is to elucidate the causal association between asthma and alopecia areata (AA) through the application of Mendelian randomization (MR) analysis, leveraging summary data from genome-wide association studies (GWAS). Additionally, it explores potential mediating factors.

Materials And Methods: Mendelian randomization (MR) analysis was employed to investigate the causal relationship between asthma and AA using genetic instrumental variables (IVs) for asthma, 91 circulating inflammatory proteins, and AA extracted from large-scale GWAS.

Ir Nanoparticles Supported on Oxygen-Deficient Vanadium Oxides Prepared by a Polyoxovanadate Precursor for Enhanced Electrocatalytic Hydrogen Evolution.

Developing highly active electrocatalysts is crucial for the application of electrocatalytic water splitting. In this study, we prepared vanadium oxide-graphene carbon nanocomposites (VO/C) with abundant defects using a carbon- and oxygen-rich hexavanadate derivative Na[VO{(OCH)CCH}] as a precursor without the addition of an extra carbon source. Subsequently, the VO/C was used as a catalyst support to load a small amount of Ir, forming the Ir/VO/C nanoelectrocatalyst.

Efficient Hydrogen Production over Molybdenum Tungsten Bimetallic Oxide NF/PMoW Catalyst on Nickel Foam.

Developing inexpensive, efficient, and stable catalysts is crucial for reducing the cost of electrolytic hydrogen production. Recently, polyoxometalates (POMs) have gained attention and widespread use due to their excellent electrocatalytic properties. This study designed and synthesized three composite materials, NF/PMoW, by using phosphomolybdic-tungstic heteropolyacids as precursors to grow in situ on nickel foam via the hydrothermal process and subsequent calcination.

Environmentally relevant concentrations of benzophenones exposure disrupt intestinal homeostasis, impair the intestinal barrier, and induce inflammation in mice.

The aim of this study is to investigate the adverse effects of benzophenones (BPs) on the intestinal tract of mice and the potential mechanism. F1-generation ICR mice were exposed to BPs (benzophenone-1, benzophenone-2, and benzophenone-3) by breastfeeding from birth until weaning, and by drinking water after weaning until maturity. The offspring mice were executed on postnatal day 56, then their distal colons were sampled.

Tris-Functionalized Polyoxotungstovanadate-Mediated Antitumor Efficacy Involves Multiple Cell Death Pathways.

Polyoxometalates (POMs) are promising inorganic drug candidates for cancer chemotherapy. They are becoming attractive because of their easy accessibility and low cost. Herein, we report the synthesis and antitumor activity studies of four Lindqvist-type POMs with mixed-addenda atoms Na[VWO{(OCH)CR}] (R=-CHOH, -CH, -CHCH) and (BuN)[VW{(OCH)CHOOCCHCH}].

CoS-MoS Nanoflower Arrays for Efficient Hydrogen Evolution Reaction in the Universal pH Range.

To explore, highly active electrocatalysts are essential for water splitting materials. Polyoxometalates (POMs) have drawn interesting attention in recent years due to their abundant structure and unique electrocatalytic properties. In this study, by using a POM-based precursor Co2Mo10, novel bimetallic sulfide (CoS-MoS) nanocomposites are rationally designed and synthesized under hydrothermal conditions.

Dynamic monitoring of TGW6 by selective autophagy during grain development in rice.

Crop yield must increase to achieve food security in the face of a growing population and environmental deterioration. Grain size is a prime breeding target for improving grain yield and quality in crop. Here, we report that autophagy emerges as an important regulatory pathway contributing to grain size and quality in rice.

Blind Detection of Broadband Signal Based on Weighted Bi-Directional Feature Pyramid Network.

With the development of wireless technology, signals propagating in space are easy to mix, so blind detection of communication signals has become a very practical and challenging problem. In this paper, we propose a blind detection method for broadband signals based on a weighted bi-directional feature pyramid network (BiFPN). The method can quickly perform detection and automatic modulation identification (AMC) on time-domain aliased signals in broadband data.

YKL-39 is an independent prognostic factor in gastric adenocarcinoma and is associated with tumor-associated macrophage infiltration and angiogenesis.

Background: Gastric cancer has a high incidence and mortality rate. Angiogenesis is necessary for tumor infiltration and metastasis and affects patient prognosis. YKL-39 has monocyte chemotactic activity and pro-angiogenic activity in some tumors.

NOX4 has the potential to be a biomarker associated with colon cancer ferroptosis and immune infiltration based on bioinformatics analysis.

Background: Colon cancer (CC) is a common tumor, but its pathogenesis is still not well understood. Competitive endogenous RNA (ceRNA) theory, ferroptosis and tumor immune infiltration may be the mechanisms of the development of cancer. The purpose of the study is to seek genes connected with both immunity and ferroptosis, and provide important molecular basis for early noninvasive diagnosis and immunotherapy of CC.

Constructed the ceRNA network and predicted a FEZF1-AS1/miR-92b-3p/ZIC5 axis in colon cancer.

The purpose of this study was to identify the role of FEZF1-AS1 in colon cancer and predicted the underlying mechanism. We extracted sequencing data of colon cancer patients from The Cancer Genome Atlas database, identified the differential expression of long noncoding RNA, microRNA, and messenger RNA, constructed a competitive endogenous RNA network, and then analyzed prognosis. Then, we used the enrichment analysis databases for functional analysis.

A Novel Necroptosis-Related Gene Signature in Skin Cutaneous Melanoma Prognosis and Tumor Microenvironment.

Necroptosis has been identified recently as a newly recognized programmed cell death that has an impact on tumor progression and prognosis, although the necroptosis-related gene (NRGs) potential prognostic value in skin cutaneous melanoma (SKCM) has not been identified. The aim of this study was to construct a prognostic model of SKCM through NRGs in order to help SKCM patients obtain precise clinical treatment strategies. RNA sequencing data collected from The Cancer Genome Atlas (TCGA) were used to identify differentially expressed and prognostic NRGs in SKCM.

COL8A1 Predicts the Clinical Prognosis of Gastric Cancer and Is Related to Epithelial-Mesenchymal Transition.

Background: Gastric cancer (GC) is the fifth most common malignant tumor and the third leading cause of cancer-related deaths. Because GC has the characteristics of high heterogeneity, unclear mechanism, limited treatment methods, and low five-year survival rate, it is necessary to find the prognostic biomarkers of GC and explore the mechanism of GC.

Methods: We first identified differentially expressed genes (DEGs) between gastric cancer and normal gastric cells through expression analysis.

An Immunity-Associated lncRNA Signature for Predicting Prognosis in Gastric Adenocarcinoma.

Background: Gastric adenocarcinoma (GAD) is one of the most common tumors in the world and the prognosis is still very poor.

Objective: We sought to identify reliable prognostic biomarkers for the progression of GAD and the sensitivity to drug therapy.

Method: The RNA sequencing data of GAD was downloaded from the Cancer Genome Atlas (TCGA) database and used for analysis.

The Potential Role of Small Nucleolar RNAs in Cancers - An Evidence Map.

Purpose: Cancer seriously endangers human health in every country of the world. New evidence shows that small nucleolar RNAs play important roles in tumorigenesis. Herein, we created this evidence map to systematically assess the impact of dysregulated snoRNAs on cancers.

Using Immune-Related lncRNA Signature for Prognosis and Response to Immunotherapy in Cutaneous Melanoma.

Background: Cutaneous melanoma is a highly malignant skin tumor, and most patients have a poor prognosis. In recent years, immunotherapy has assumed an important role in the treatment of advanced cutaneous melanoma, but only a small percentage of patients benefit from immunotherapy. A growing number of studies have demonstrated that the prognosis of patients with cutaneous melanoma is closely related to long non-coding RNA and the tumor immune microenvironment.

Ir-based electrocatalysts promoted by TME-substituted polyoxovanadate-derived vanadium carbide for efficient hydrogen evolution and oxygen evolution.

A novel trimethylolethane (TME)-substituted polyoxovanadate (POV) was designed as a precursor to prepare ultrasmall vanadium carbide nanoparticles, which markedly promoted the hydrogen evolution reaction and oxygen evolution reaction of iridium (Ir)-based electrocatalysts. This work is the first example employing organic ligand-substituted POV as the precursor for metal carbide, and is also the first combination of Ir and vanadium carbide, providing new insights into the design of excellent electrocatalysts.